PT - JOURNAL ARTICLE AU - Robert L Owens TI - Long-Term Domiciliary Noninvasive Ventilation for COPD AID - 10.4187/respcare.09052 DP - 2021 Jul 01 TA - Respiratory Care PG - 1120--1127 VI - 66 IP - 7 4099 - http://rc.rcjournal.com/content/66/7/1120.short 4100 - http://rc.rcjournal.com/content/66/7/1120.full AB - COPD can lead to abnormalities in oxygenation as well as ventilation. Thanks to pioneering work by Dr Thomas Petty, supplemental oxygen therapy has been shown to improve morbidity and mortality for individuals with COPD and severe daytime hypoxemia. However, efforts to augment ventilation have been less uniformly successful. Recent studies employing a so-called high-intensity noninvasive ventilation strategy, which used high inspiratory pressures and backup breathing frequency to reduce arterial carbon dioxide levels, have shown improved quality of life and reduced mortality. Thus, efforts are underway to better identify and treat patients with COPD who might benefit from noninvasive ventilation, though many practical questions remain.