RT Journal Article SR Electronic T1 A Case of Unexplained Hypoxemia JF Respiratory Care FD American Association for Respiratory Care SP 1963 OP 1966 DO 10.4187/respcare.01612 VO 57 IS 11 A1 Poul Henning Madsen A1 Søren Hess A1 Helle Dall Madsen YR 2012 UL http://rc.rcjournal.com/content/57/11/1963.abstract AB We present a patient with acute-onset dyspnea and unexplained severe hypoxemia. No signs of severe cardiopulmonary disease, pulmonary arterial hypertension, or pulmonary embolism were present. The patient was diagnosed with hepatopulmonary syndrome, since liver disease of alcoholic origin was present, markedly increased alveolar-arterial oxygen difference existed, and intrapulmonary vascular dilations were demonstrated. The condition of the patient did not improve and he was referred for liver transplantation, which is the only treatment option with documented efficacy. The case highlights the importance of thinking outside the thorax when evaluating patients with dyspnea.