PT  - JOURNAL ARTICLE
AU  - Kasper M Sørensen
AU  - Rebecca V Leicht
AU  - Christian J Carlsson
AU  - Mikkel Elvekjaer
AU  - Celeste Porsbjerg
AU  - Eske K Aasvang
AU  - Christian S Meyhoff
TI  - Agreement Between Transcutaneous Monitoring and Arterial Blood Gases During COPD Exacerbation
AID  - 10.4187/respcare.08510
DP  - 2021 Oct 01
TA  - Respiratory Care
PG  - 1560--1566
VI  - 66
IP  - 10
4099  - http://rc.rcjournal.com/content/66/10/1560.short
4100  - http://rc.rcjournal.com/content/66/10/1560.full
AB  - BACKGROUND: Transcutaneous measurements of CO2 and O2 (, ) are noninvasive and allow for continuous monitoring in adults with exacerbation of COPD, but substantial accuracy issues may exist. We investigated agreement between results of arterial blood gas analysis and transcutaneous measurements of CO2 and O2 in patients with COPD.METHODS: Adult subjects were monitored after acute admission to a respiratory intermediate care unit or ICU due to exacerbation of COPD and with ongoing noninvasive ventilation or immediately following extubation. Monitored variables were continuous transcutaneous measurement and simultaneous routine arterial blood gas analysis. Agreement between measurements was assessed by calculating bias with 95% limits of agreement for single-point estimates of versus and versus , and for changes in transcutaneous measurements between 2 time points ( and ). We considered limits of agreement within ± 7.5 mm Hg to be acceptable.RESULTS: A total of 57 transcutaneous measurements were made in 20 subjects for comparison with concurrent arterial blood gas analysis at 36 time points. The bias (limits of agreement) for and was 2.5 mm Hg (–10.6 to 15.6 mm Hg) and 11.2 mm Hg (–28.2 to 50.6 mm Hg), respectively. The bias for and was 2.3 mm Hg (–3.8 to 8.3 mm Hg) and –5.3 mm Hg (–37.5 to 27 mm Hg), respectively.CONCLUSIONS: and did not accurately reflect results from arterial blood gas analyses in this study of mostly hypercapnic subjects. Agreement between changes in CO2 during the monitoring period was acceptable, however, and transcutaneous monitoring may be used for continuous monitoring of in conjunction with arterial blood gas analysis for reference.