RT Journal Article SR Electronic T1 Different Tracheotomy Tube Diameters Influence Diaphragmatic Effort and Indices of Weanability in Difficult to Wean Patients JF Respiratory Care FD American Association for Respiratory Care SP 2012 OP 2018 DO 10.4187/respcare.01747 VO 57 IS 12 A1 Ilaria Valentini A1 Eva Tonveronachi A1 Cesare Gregoretti A1 Chiara Mega A1 Luca Fasano A1 Lara Pisani A1 Stefano Nava YR 2012 UL http://rc.rcjournal.com/content/57/12/2012.abstract AB OBJECTIVE: To determine the effects of different tracheotomy tube sizes on diaphragm effort and weanability indices. METHODS: Ten tracheotomized and difficult to wean subjects were randomized to 2 T-piece trials, with different tracheotomy tube diameters: inner diameters 8 mm and 6.5 mm. Diaphragm pressure-time product per min. (PTPdi/min), lung compliance and resistance (CL and RL), breathing pattern, tension-time index of the diaphragm (TTdi), and the ratio of breathing frequency to tidal volume (f/VT) were recorded. In an in vitro model, the flow-pressure relationship was measured using the 2 tracheotomy tubes and 2 endotracheal tubes of the same diameter. RESULTS: The use of a smaller diameter resulted in an increase of PTPdi (337.63 ± 194.35 cm H2O · s/min vs 263.28 ± 156.23 cm H2O · s/min for 6.5 mm and 8 mm, respectively, P = .004) and RL (16.74 ± 8.10 cm H2O · s/min vs 11.72 ± 7.88 cm H2O · s/min, respectively, P = .008). Both weanability indices were also significantly higher using the smaller tube: f/VT 93.32 ± 20.91 vs 77.06 ± 19.26 for 6.5 mm and 8 mm, respectively, P < .02; TTdi 0.09 ± 0.052 vs 0.08 ± 0.04, respectively, P < .02. In vitro measurements confirmed that the resistances were higher with the smaller diameter and similar between the tracheotomy tubes and the endotracheal tubes of the same diameters. CONCLUSIONS: In tracheotomized difficult to wean subjects the decrease of the tracheotomy tube size was associated with an increased PTPdi, f/VT, and TTdi, that were otherwise normal, using a higher diameter. The in vitro study showed that the resistances increased similarly for tracheotomy tube and endotracheal tube, decreasing the diameter and increasing the flows.