TY - JOUR T1 - Cardiopulmonary Rehabilitation Enhances Heart Rate Recovery in Patients With COPD JF - Respiratory Care SP - 2095 LP - 2103 DO - 10.4187/respcare.01485 VL - 57 IS - 12 AU - Vasiliki V Georgiopoulou AU - Stavros Dimopoulos AU - Dimitrios Sakellariou AU - Ourania Papazachou AU - Vasiliki Gerovasili AU - Athanasios Tasoulis AU - Varvara Agapitou AU - Ioannis Vogiatzis AU - Charis Roussos AU - Serafim Nanas Y1 - 2012/12/01 UR - http://rc.rcjournal.com/content/57/12/2095.abstract N2 - BACKGROUND: Autonomic dysfunction is present early in the course of COPD, and is associated with adverse outcomes. We utilized heart rate recovery, a simple and validated index of autonomic balance, to investigate the effects of exercise training on autonomic dysfunction in patients with COPD. METHODS: We evaluated 45 stable subjects with COPD who participated in a 36-session exercise-based cardiopulmonary rehabilitation program. Subjects underwent maximal cardiopulmonary exercise testing at baseline and after completion of the rehabilitation program. We recorded exercise testing parameters and heart rate during rest, exercise, and recovery. Heart rate recovery was calculated as heart rate at peak exercise minus heart rate at the first minute of recovery. RESULTS: Thirty-nine subjects (age 66.3 ± 7.8 y, 90% male, body mass index 27.1 ± 4.1 kg/m2, FEV1 45.7 ± 18.7%) completed the program. In these subjects, heart rate recovery increased from 16.2 ± 8.0 beats/min to 18.4 ± 8.4 beats/min (P = .01), resting heart rate decreased from 88.0 ± 10.7 beats/min to 83.3 ± 10.5 beats/min (P = .004), and heart rate at anaerobic threshold decreased from 109.0 ± 12.5 beats/min to 105.5 ± 11.7 beats/min (P = .040). In addition, oxygen consumption (V̇O2) increased from 14.3 ± 3.7 mL/kg/min to 15.2 ± 3.8 mL/kg/min at peak exercise, and from 9.7 ± 2.4 mL/kg/min to 10.4 ± 2.6 mL/kg/min at anaerobic threshold (both P = .02), while the V̇O2/t slope increased from –0.32 ± 0.16 mL/kg/min2 to –0.38 ± 0.19 mL/kg/min2 (P = .003). Parameters of ventilatory performance improved also. CONCLUSIONS: In subjects with COPD, exercise-based rehabilitation improves heart rate recovery, modestly though, which indicates a degree of attenuated autonomic dysfunction. Exercise and muscular oxidative capacity, as expressed by V̇O2/t slope, is also improved. ER -