TY - JOUR T1 - Absence of Airway Secretion Accumulation Predicts Tolerance of Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis JF - Respiratory Care SP - 1424 LP - 1432 DO - 10.4187/respcare.02103 VL - 58 IS - 9 AU - Nadia Vandenberghe AU - Anne-Evelyne Vallet AU - Thierry Petitjean AU - Pierre Le Cam AU - Stéphane Peysson AU - Claude Guérin AU - Frédéric Dailler AU - Sylvie Jay AU - Vincent Cadiergue AU - Françoise Bouhour AU - Isabelle Court-Fortune AU - Jean-Philippe Camdessanche AU - Jean-Christophe Antoine AU - François Philit AU - Pascal Beuret AU - Sylvie Bin-Dorel AU - Christophe Vial AU - Emmanuel Broussolle Y1 - 2013/09/01 UR - http://rc.rcjournal.com/content/58/9/1424.abstract N2 - OBJECTIVE: To assess factors that predict good tolerance of noninvasive ventilation (NIV), in order to improve survival and quality of life in subjects with amyotrophic lateral sclerosis. METHODS: We conducted a prospective study in subjects with amyotrophic lateral sclerosis and requiring NIV. The primary end point was NIV tolerance at 1 month. Subjects, several of whom failed to complete the study, were classified as “tolerant” or “poorly tolerant,” according to the number of hours of NIV use (more or less than 4 h per night, respectively). RESULTS: Eighty-one subjects, 73 of whom also attended the 1-month follow-up visit, participated over 34 months. NIV tolerance after the first day of utilization predicted tolerance at 1 month (77.6% and 75.3% of subjects, respectively). Multivariate analysis disclosed 3 factors predicting good NIV tolerance: absence of airway secretions accumulation prior to NIV onset (odds ratio 11.5); normal bulbar function at initiation of NIV (odds ratio 8.5); and older age (weakly significant, odds ratio 1.1). CONCLUSION: Our study reveals 3 factors that are predictive of good NIV tolerance, in particular the absence of airway secretion accumulation, which should prompt NIV initiation before its appearance. ER -