RT Journal Article
SR Electronic
T1 Absence of Airway Secretion Accumulation Predicts Tolerance of Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis
JF Respiratory Care
FD American Association for Respiratory Care
SP 1424
OP 1432
DO 10.4187/respcare.02103
VO 58
IS 9
A1 Vandenberghe, Nadia
A1 Vallet, Anne-Evelyne
A1 Petitjean, Thierry
A1 Le Cam, Pierre
A1 Peysson, Stéphane
A1 Guérin, Claude
A1 Dailler, Frédéric
A1 Jay, Sylvie
A1 Cadiergue, Vincent
A1 Bouhour, Françoise
A1 Court-Fortune, Isabelle
A1 Camdessanche, Jean-Philippe
A1 Antoine, Jean-Christophe
A1 Philit, François
A1 Beuret, Pascal
A1 Bin-Dorel, Sylvie
A1 Vial, Christophe
A1 Broussolle, Emmanuel
YR 2013
UL http://rc.rcjournal.com/content/58/9/1424.abstract
AB OBJECTIVE: To assess factors that predict good tolerance of noninvasive ventilation (NIV), in order to improve survival and quality of life in subjects with amyotrophic lateral sclerosis. METHODS: We conducted a prospective study in subjects with amyotrophic lateral sclerosis and requiring NIV. The primary end point was NIV tolerance at 1 month. Subjects, several of whom failed to complete the study, were classified as “tolerant” or “poorly tolerant,” according to the number of hours of NIV use (more or less than 4 h per night, respectively). RESULTS: Eighty-one subjects, 73 of whom also attended the 1-month follow-up visit, participated over 34 months. NIV tolerance after the first day of utilization predicted tolerance at 1 month (77.6% and 75.3% of subjects, respectively). Multivariate analysis disclosed 3 factors predicting good NIV tolerance: absence of airway secretions accumulation prior to NIV onset (odds ratio 11.5); normal bulbar function at initiation of NIV (odds ratio 8.5); and older age (weakly significant, odds ratio 1.1). CONCLUSION: Our study reveals 3 factors that are predictive of good NIV tolerance, in particular the absence of airway secretion accumulation, which should prompt NIV initiation before its appearance.