RT Journal Article
SR Electronic
T1 Emergency Department Management of Suspected Carbon Monoxide Poisoning: Role of Pulse CO-Oximetry
JF Respiratory Care
FD American Association for Respiratory Care
SP 1614
OP 1620
DO 10.4187/respcare.02313
VO 58
IS 10
A1 Mustapha Sebbane
A1 Pierre-Géraud Claret
A1 Grégoire Mercier
A1 Sophie Lefebvre
A1 Richard Théry
A1 Richard Dumont
A1 Michel Maillé
A1 Jean-Paul Richard
A1 Jean-Jacques Eledjam
A1 Jean-Emmanuel de La Coussaye
YR 2013
UL http://rc.rcjournal.com/content/58/10/1614.abstract
AB BACKGROUND: The RAD-57 pulse CO-oximeter is a lightweight device allowing noninvasive measurement of blood carboxyhemoglobin (SpCO). We assessed the diagnostic value of pulse CO-oximetry, comparing SpCO values from the RAD-57 to standard laboratory blood carboxyhemoglobin (COHb) measurement in emergency department patients with suspected carbon monoxide (CO) poisoning. METHODS: This was a prospective, diagnostic accuracy study according to the Standards for the Reporting of Diagnostic Accuracy Studies criteria in consecutive adult emergency department patients with suspected CO poisoning. SpCO was measured with the RAD-57 simultaneously with blood sampling for laboratory blood gas analysis. We made no changes to our standard management of CO poisoning. Blood COHb > 5% for non-smokers, and > 10% for smokers were applied as the reference standard. RESULTS: We included 93 subjects: 37 smokers and 56 non-smokers. CO poisoning was diagnosed in 26 subjects (28%). The SpCO values ranged from 1% to 30%, with a median of 4% (IQR 2.7–7.3%). The COHb values ranged from 0% to 34%, with a median of 5% (IQR 2–9%). The mean differences between the COHb and SpCO values were −0.2% ± 3.3% (95% limits of agreement of −6.7% and 6.3%) for the whole cohort, −0.7% (limits of agreement −7.7% and 6.2%) for the non-smokers, and 0.6% (limits of agreement −5.0% and 6.2%) for the smokers. The optimal thresholds for detecting CO poisoning were SpCO of 9% and 6% for smokers and non-smokers, respectively. CONCLUSIONS: SpCO measured with the RAD-57 was not a substitute for standard blood COHb measurement. However, noninvasive pulse CO-oximetry could be useful as a first-line screening test, enabling rapid detection and management of CO-poisoned patients in the emergency department.