RT Journal Article
SR Electronic
T1 <span hwp:id="article-title-1" class="article-title">Ventilator-Induced Lung Injury: Minimizing Its Impact in Patients With or at Risk for ARDS</span><span hwp:id="article-title-51" class="sub-article-title">Discussion</span>
JF Respiratory Care
FD American Association for Respiratory Care
SP 927
OP 937
DO 10.4187/respcare.02347
VO 58
IS 6
A1 Biehl, Michelle
A1 Kashiouris, Markos G
A1 Gajic, Ognjen
YR 2013
UL http://rc.rcjournal.com/content/58/6/927.abstract
AB Ventilator-induced lung injury (VILI) results from injury to the blood-gas barrier caused by mechanical ventilation. The determinants of VILI are more complex than originally thought, and include the nature, duration, and intensity of the exposure, as well the pattern of initial insult to the lung. Lung-protective mechanical ventilation founded on these basic principles resulted in improved hospital and long-term mortality. The purpose of this review is to provide a comprehensive assessment of the pathogenesis of VILI and its determinants. We also discuss the best preventive approach in patients with or at risk for ARDS and critically appraise the most recent evidence, expert opinion, and implementation of the acquired knowledge to the bedside. Discussion