RT Journal Article
SR Electronic
T1 Physiologic Markers of Disease Severity in ARDS
JF Respiratory Care
FD American Association for Respiratory Care
SP respcare.11100
DO 10.4187/respcare.11100
A1 Ferraz, Joao F F M
A1 Siuba, Matthew T.
A1 Krishnan, Sudhir
A1 Chatburn, Robert
A1 Mireles-Cabodevila, Eduardo
A1 Duggal, Abhijit
YR 2023
UL http://rc.rcjournal.com/content/early/2023/07/12/respcare.11100.abstract
AB Despite its significant limitations, the ratio between the partial pressure of arterial oxygen and the fraction of inspired oxygen, the PaO2/FiO2 ratio, remains the standard tool to classify disease severity in ARDS. Treatment decisions and research enrollment have depended on this parameter for over fifty years. In addition, several variables have been studied over the past few decades, incorporating other physiologic considerations such as ventilation efficiency, lung mechanics, and right ventricular performance. This review describes the strengths and limitations of all relevant parameters, with the goal of helping us better understand disease severity and possible future treatment targets.