TY - JOUR T1 - Tiotropium Versus Placebo for Inadequately Controlled Asthma: A Meta-Analysis JF - Respiratory Care SP - 654 LP - 666 DO - 10.4187/respcare.02703 VL - 59 IS - 5 AU - Jing-wei Tian AU - Jin-wu Chen AU - Rui Chen AU - Xin Chen Y1 - 2014/05/01 UR - http://rc.rcjournal.com/content/59/5/654.abstract N2 - OBJECTIVE: This meta-analysis was performed to evaluate the efficacy and safety of the addition of tiotropium to standard treatment regimens for inadequately controlled asthma. METHODS: A systematic search was made of PubMed, EMBASE, MEDLINE, and CENTRAL databases, and ClinicalTrials.gov, and a hand search of leading respiratory journals. Randomized, double-blind clinical trials on the treatment of inadequately controlled asthma for ≥ 4 weeks with the addition of tiotropium, compared with placebo, were reviewed. Studies were pooled to odds ratio (OR) and weighted mean differences (WMDs), with 95% CI. RESULTS: Six trials met the inclusion criteria. The addition of tiotropium, compared with placebo, significantly improved all spirometric indices, including morning and evening peak expiratory flow (WMD 20.59 L/min, 95% CI 15.36–25.81 L/min, P < .001; and WMD 24.95 L/min, 95% CI 19.22–30.69 L/min, P < .001, respectively), trough and peak FEV1 (WMD 0.13 L, 95% CI 0.09–0.18 L, P < .001; and WMD 0.10 L, 95% CI 0.06–0.14 L, P < .001, respectively), the area under the curve of the first 3 h of FEV1 (WMD 0.13 L, 95% CI 0.08–0.18 L, P < .001), trough and peak FVC (WMD 0.1 L, 95% CI 0.05–0.15 L, P < .001; and WMD 0.08 L, 95% CI 0.04–0.13 L, P < .001, respectively), the area under the curve of the first 3 h of FVC (WMD 0.11 L, 95% CI 0.06–0.15 L, P < .001). The mean change in the 7-point Asthma Control Questionnaire score (WMD −0.12, 95% CI −0.21 to −0.03, P = .01) was markedly lower in tiotropium group, but not clinically important. There were no significant differences in Asthma Quality of Life Questionnaire score (WMD 0.09, 95% CI −0.01 to 0.20, P = .09), night awakenings (WMD 0.00, 95% CI −0.05 to 0.05, P = .99) or rescue medication use (WMD −0.18, 95% CI −0.36 to 0.00, P = .06). No significant increase was noticed in adverse events in the tiotropium group (OR 0.80, 95% CI 0.62–1.03, P = .08). CONCLUSIONS: The addition of tiotropium to standard treatment regimens has significantly improved lung function without increasing adverse events in patients with inadequately controlled asthma. Long-term trials are required to assess the effects of the addition of tiotropium on asthma exacerbations and mortality. ER -