TY - JOUR T1 - Reversible Pre-Capillary Pulmonary Hypertension Due to Dasatinib JF - Respiratory Care SP - e77 LP - e80 DO - 10.4187/respcare.02692 VL - 59 IS - 5 AU - Herminia L Buchelli Ramirez AU - Celso M Álvarez Álvarez AU - José J Rodríguez Reguero AU - Marta M García Clemente AU - Pere Casan Clarà Y1 - 2014/05/01 UR - http://rc.rcjournal.com/content/59/5/e77.abstract N2 - Pulmonary arterial hypertension and secondary pleural effusion have been reported in association with long-term therapy with the multi-tyrosine kinase inhibitor dasatinib, approved for the treatment of chronic myeloid leukemia. Here, we present the case of a 50-year-old man, diagnosed with chronic myeloid leukemia in August 2003, who developed pulmonary arterial hypertension after > 4 years of treatment with dasatinib. The complete remission of pulmonary arterial hypertension following dasatinib discontinuation suggests an etiological role of the drug in its development, although the administration of sildenafil may have played a therapeutic role. ER -