RT Journal Article
SR Electronic
T1 Physiologic Markers of Disease Severity in ARDS
JF Respiratory Care
FD American Association for Respiratory Care
SP 1708
OP 1718
DO 10.4187/respcare.11100
VO 68
IS 12
A1 Ferraz, Joao F F M
A1 Siuba, Matthew T
A1 Krishnan, Sudhir
A1 Chatburn, Robert L
A1 Mireles-Cabodevila, Eduardo
A1 Duggal, Abhijit
YR 2023
UL http://rc.rcjournal.com/content/68/12/1708.abstract
AB Despite its significant limitations, the PaO2/FIO2 remains the standard tool to classify disease severity in ARDS. Treatment decisions and research enrollment have depended on this parameter for over 50 years. In addition, several variables have been studied over the past few decades, incorporating other physiologic considerations such as ventilation efficiency, lung mechanics, and right-ventricular performance. This review describes the strengths and limitations of all relevant parameters, with the goal of helping us better understand disease severity and possible future treatment targets.