@article {Someya75, author = {Fujiko Someya and Naoki Mugii and Minoru Hasegawa and Tetsutarou Yahata and Takao Nakagawa}, title = {Predictors of Exercise-Induced Oxygen Desaturation in Systemic Sclerosis Patients With Interstitial Lung Disease}, volume = {59}, number = {1}, pages = {75--80}, year = {2014}, doi = {10.4187/respcare.02452}, publisher = {Respiratory Care}, abstract = {BACKGROUND: The diffusion capacity of the lung for carbon monoxide (DLCO) is a good marker of disease severity in patients with idiopathic interstitial pneumonia, and is associated with oxygen saturation; however, little is known about DLCO in systemic sclerosis patients with interstitial lung disease. We studied potential predictors of exercise-induced oxygen desaturation in patients with systemic sclerosis. METHODS: Data were collected prospectively from 80 of 110 consecutive systemic sclerosis patients with normal oxygen saturation (\> 95\%) at rest, who could perform the 6-min walk test without physical discomfort, including leg pain. Pulmonary function tests and echocardiography were collected from all subjects. RESULTS: Thirty subjects showed a >= 4\% decline in oxygen saturation during the 6-min walk test (desaturation group). The other subjects were assigned to the normoxic group. The percent-of-predicted values for FVC, FEV1, total lung capacity, DLCO, and DLCO/alveolar volume were lower, and FEV1/FVC was higher, in the desaturation group. Logistic regression analysis showed the percent-of-predicted DLCO as a highly accurate predictor of exercise-induced oxygen desaturation: the area under the receiver operating characteristic curve was 0.92 (cutoff point 56.3\%, sensitivity 0.83, specificity 0.86). Five subjects over the cutoff point of the percent-of-predicted DLCO in the desaturation group could not be distinguished from the normoxic subjects with the lung-volume measurements or right-ventricular systolic pressure. CONCLUSIONS: The factor underlying exercise-induced oxygen desaturation appeared to be reduced percent-of-predicted DLCO, which was useful as a predictor in over 80\% of the subjects.}, issn = {0020-1324}, URL = {https://rc.rcjournal.com/content/59/1/75}, eprint = {https://rc.rcjournal.com/content/59/1/75.full.pdf}, journal = {Respiratory Care} }