RT Journal Article
SR Electronic
T1 Experimental Model of Atelectasis in Newborn Piglets
JF Respiratory Care
FD American Association for Respiratory Care
SP 121
OP 126
DO 10.4187/respcare.02352
VO 59
IS 1
A1 Comaru, Talitha
A1 Fiori, Humberto Holmer
A1 Fiori, Renato Machado
A1 Padoim, Priscila
A1 Stivanin, Jaqueline Basso
A1 da Silva, Vinicius Duval
YR 2014
UL http://rc.rcjournal.com/content/59/1/121.abstract
AB BACKGROUND: There are few studies using animal models in chest physical therapy. However, there are no models to assess these effects in newborns. This study aimed to develop a model of obstructive atelectasis induced by artificial mucus injection in the lungs of newborn piglets, for the study of neonatal physiotherapy. METHODS: Thirteen newborn piglets received artificial mucus injection via the endotracheal tube. X-rays and blood gas analysis confirmed the atelectasis. RESULTS: The model showed consistent results between oxygenation parameters and radiological findings. Ten (76.9%) of the 13 piglets responded to the intervention. This did not significantly differ from the expected percentage of 50% by the binomial test (95% CI 46.2–95%, P = .09). CONCLUSIONS: Our model of atelectasis in newborn piglets is both feasible and appropriate to evaluate the impact of physical therapies on atelectasis in newborns.