PT - JOURNAL ARTICLE AU - Rafael S dos Santos AU - Márcio VF Donadio AU - Gabriela V da Silva AU - Clarissa N Blattner AU - Denizar AS Melo AU - Fernanda B Nunes AU - Fernando S Dias AU - Eamim D Squizani AU - Leonardo Pedrazza AU - Isabella Gadegast AU - Jarbas R de Oliveira TI - Immediate Effects of Chest Physiotherapy on Hemodynamic, Metabolic, and Oxidative Stress Parameters in Subjects With Septic Shock AID - 10.4187/respcare.02859 DP - 2014 Sep 01 TA - Respiratory Care PG - 1398--1403 VI - 59 IP - 9 4099 - http://rc.rcjournal.com/content/59/9/1398.short 4100 - http://rc.rcjournal.com/content/59/9/1398.full AB - BACKGROUND: Septic shock presents as a continuum of infectious events, generating tissue hypoxia and hypovolemia, and increased oxidative stress. Chest physiotherapy helps reduce secretion, improving dynamic and static compliance, as well as improving secretion clearance and preventing pulmonary complications. The purpose of this study was to evaluate the immediate effect of chest physiotherapy on hemodynamic, metabolic, inflammatory, and oxidative stress parameters in subjects in septic shock. METHODS: We conducted a quasi-experimental study in 30 subjects in septic shock, who underwent chest physiotherapy, without associated heart diseases and with vasopressors < 0.5 μg/kg/min. Venous and arterial blood gases, clinical and hemodynamic data, inflammatory data, lactate, and oxidative stress were evaluated before and 15 min after physiotherapy. RESULTS: Thirty subjects with a mean age of 61.8 ± 15.9 y and Sequential Organ Failure Assessment of 8 (range 6–10) were included. Chest physiotherapy caused a normalization of pH (P = .046) and PaCO2 (P = .008); reduction of lactate (P = .001); and an increase in PaO2 (P = .03), arterial oxygen saturation (P = .02), and PaO2/FIO2 (P = .034), 15 min after it was applied. CONCLUSIONS: The results indicate that chest physiotherapy has immediate effects, improving oxygenation and reducing lactate and oxidative damage in subjects in septic shock. However, it does not cause alterations in the inflammatory and hemodynamic parameters.