RT Journal Article
SR Electronic
T1 Effect of Drug Targeting Nebulization on Lung Deposition: A Randomized Crossover Scintigraphic Comparison Between Central and Peripheral Delivery
JF Respiratory Care
FD American Association for Respiratory Care
SP 1501
OP 1507
DO 10.4187/respcare.03068
VO 59
IS 10
A1 Reychler, Gregory
A1 Aubriot, Anne-Sophie
A1 Depoortere, Virginie
A1 Jamar, François
A1 Liistro, Giuseppe
YR 2014
UL http://rc.rcjournal.com/content/59/10/1501.abstract
AB BACKGROUND: Recent technological advances in nebulization permit researchers to target specific parts of the lungs by modifying delivery method. The aim of this study was to compare the central and peripheral targeted modalities of administration. METHODS: Lung and regional deposition of inhaled technetium-99m diethylene triamine penta-acetic was measured by scintigraphy after peripheral and central targeted modalities of administration with an Akita device in 6 healthy subjects. RESULTS: Drug targeting nebulization delivered a large amount of drug into the peripheral part of the lung independent of the modality (outer-to-inner deposition ratio of 1.24 ± 0.21 vs 1.22 ± 0.14 for central and peripheral modalities, respectively), but there was no difference in lung deposition (whole-body deposition, 83.3 ± 6.5% vs 82.8 ± 7.3%, P = .86) or regional deposition (P = .77) between both modalities. The extrathoracic deposition was < 20% of the whole-body deposition, without a difference between modalities (P = .86). CONCLUSIONS: This study shows for the first time that choosing 2 different specific drug targeting nebulization modes does not influence the amount of drug delivered into the lung in healthy male subjects. Moreover, the modes do not modify the site of deposition under the conditions of our study.