RT Journal Article
SR Electronic
T1 Role of Alveolar-Arterial Difference in Estimation of Extravascular Lung Water in COVID-19-Related ARDS
JF Respiratory Care
FD American Association for Respiratory Care
SP 1548
OP 1554
DO 10.4187/respcare.11804
VO 69
IS 12
A1 Kutej, Martin
A1 Sagan, Jiri
A1 Ekrtova, Tereza
A1 Strakova, Hana
A1 Buzga, Marek
A1 Burda, Michal
A1 Maca, Jan
YR 2024
UL http://rc.rcjournal.com/content/69/12/1548.abstract
AB BACKGROUND: The dominant feature of COVID-19-associated ARDS is gas exchange impairment. Extravascular lung water index is a surrogate for lung edema and reflects the level of alveolocapillary disruption. The primary aim was the prediction of extravascular lung water index by the alveolar-arterial oxygen difference. The secondary aims were in determining the relationship between the extravascular lung water index and other oxygenation parameters, the , end-tidal oxygen concentration, pulmonary oxygen gradient ( minus end-tidal oxygen concentration), and .METHODS: This observational prospective single-center study was performed at the Department of Anaesthesiology and Intensive Care, The University Hospital in Ostrava, The Czech Republic, during the COVID-19 pandemic, from March 20, 2020, until May 24, 2021.RESULTS: The relationship between the extravascular lung water index and alveolar-arterial oxygen difference showed only a mild-to-moderate correlation (r = 0.33, P < .001). Other extravascular lung water index correlations were as follows: (r = 0.33, P < .001), end-tidal oxygen concentration (r = 0.26, P = .0032), minus end-tidal oxygen concentration (r = 0.15, P = .0624), and (r = –0.15, P = .01).CONCLUSIONS: The alveolar-arterial oxygen difference does not reliably correlate with the extravascular lung water index and the degree of lung edema in COVID-19–associated ARDS.