TY - JOUR T1 - Aerosol Medications for Treatment of Mucus Clearance Disorders JF - Respiratory Care SP - 825 LP - 832 DO - 10.4187/respcare.04087 VL - 60 IS - 6 AU - Bruce K Rubin Y1 - 2015/06/01 UR - http://rc.rcjournal.com/content/60/6/825.abstract N2 - Airway mucus hypersecretion and secretion retention can result from inflammation, irritation, stimulation, or mucus-producing tumors. Secretion clearance can be furthered hampered by ciliary dysfunction and by weakness or restrictive lung disease, leading to an ineffective cough. There are a number of different mucoactive medications that have been used to reduce hypersecretion, make secretions easier to transport, or increase the efficiency of cough or mucus clearance. In this paper, I review the pathophysiology of secretory hyper-responsiveness and mucus hypersecretion and discuss the different aerosol medications that can be used to augment secretion clearance. ER -