RT Journal Article SR Electronic T1 Use of Heliox Delivered via High-Flow Nasal Cannula to Treat an Infant With Coronavirus-Related Respiratory Infection and Severe Acute Air-Flow Obstruction JF Respiratory Care FD American Association for Respiratory Care SP e166 OP e170 DO 10.4187/respcare.02728 VO 59 IS 11 A1 Sherwin E Morgan A1 Kirissa Vukin A1 Steve Mosakowski A1 Patti Solano A1 Lolita Stanton A1 Lucille Lester A1 Romeen Lavani A1 Jesse B Hall A1 Avery Tung YR 2014 UL http://rc.rcjournal.com/content/59/11/e166.abstract AB Heliox, a helium-oxygen gas mixture, has been used for many decades to treat obstructive pulmonary disease. The lower density and higher viscosity of heliox relative to nitrogen-oxygen mixtures can significantly reduce airway resistance when an anatomic upper air-flow obstruction is present and gas flow is turbulent. Clinically, heliox can decrease airway resistance in acute asthma in adults and children and in COPD. Heliox may also enhance the bronchodilating effects of β-agonist administration for acute asthma. Respiratory syndromes caused by coronavirus infections in humans range in severity from the common cold to severe acute respiratory syndrome associated with human coronavirus OC43 and other viral strains. In infants, coronavirus infection can cause bronchitis, bronchiolitis, and pneumonia in variable combinations and can produce enough air-flow obstruction to cause respiratory failure. We describe a case of coronavirus OC43 infection in an infant with severe acute respiratory distress treated with heliox inhalation to avoid intubation.