PT  - JOURNAL ARTICLE
AU  - Martínez, Daniel
AU  - Sancho, Jesús
AU  - Servera, Emilio
AU  - Marín, Julio
TI  - Tolerance of Volume Control Noninvasive Ventilation in Subjects With Amyotrophic Lateral Sclerosis
AID  - 10.4187/respcare.04172
DP  - 2015 Dec 01
TA  - Respiratory Care
PG  - 1765--1771
VI  - 60
IP  - 12
4099  - http://rc.rcjournal.com/content/60/12/1765.short
4100  - http://rc.rcjournal.com/content/60/12/1765.full
AB  - BACKGROUND: Noninvasive ventilation (NIV) tolerance has been identified as an independent predictor of survival in amyotrophic lateral sclerosis (ALS). Volume control continuous mandatory ventilation (VC-CMV) NIV has been associated with poor tolerance. The aim of this study was to determine the tolerance of subjects with ALS to VC-CMV NIV.METHODS: This was a prospective study involving subjects with ALS who were treated with VC-CMV NIV. Respiratory and functional parameters were recorded when the subjects began ventilatory support. NIV tolerance was evaluated after 3 months.RESULTS: Eighty-seven subjects with ALS were included. After 3 months, 80 subjects (92%) remained tolerant of NIV. Tolerant subjects presented greater survival (median 22.0 months, 95% CI 14.78–29.21) than intolerant subjects (median 6.0 months, 95% CI 0.86–11.13) (P = .03). The variables that best predicted NIV tolerance were mechanically assisted cough peak flow (P = .01) and percentage of time spent with SpO2 < 90% at night while on NIV (P = .03)CONCLUSIONS: VC-CMV NIV provides high rates of NIV tolerance in subjects with ALS. Mechanically assisted cough peak flow and percentage of time spent with SpO2 < 90% at night while using NIV are the 2 factors associated with tolerance of VC-CMV NIV in subjects with ALS.