RT Journal Article SR Electronic T1 Use and Outcomes of Noninvasive Ventilation for Acute Respiratory Failure in Different Age Groups JF Respiratory Care FD American Association for Respiratory Care SP 36 OP 43 DO 10.4187/respcare.03966 VO 61 IS 1 A1 Aylin Ozsancak Ugurlu A1 Samy S Sidhom A1 Ali Khodabandeh A1 Michael Ieong A1 Chester Mohr A1 Denis Y Lin A1 Irwin Buchwald A1 Imad Bahhady A1 John Wengryn A1 Vinay Maheshwari A1 Nicholas S Hill YR 2016 UL http://rc.rcjournal.com/content/61/1/36.abstract AB BACKGROUND: The prevalence of chronic disease and do-not-intubate status increases with age. Thus, we aimed to determine characteristics and outcomes associated with noninvasive ventilation (NIV) use for acute respiratory failure (ARF) in different age groups.METHODS: A database comprising prospective data collected on site on all adult patients with ARF requiring ventilatory support from 8 acute care hospitals in Massachusetts was used.RESULTS: From a total of 1,225 ventilator starts, overall NIV utilization, success, and in-hospital mortality rates were 22, 54, and 18% in younger (18–44 y); 34, 65, and 13% in middle-aged (45–64 y); 49, 68, and 17% in elderly (65–79 y); and 47, 76, and 24% in aged (≥80 y) groups, respectively (P < .001, P = .08, and P = .11, respectively). NIV use for cardiogenic pulmonary edema and subjects with a do-not-intubate order increased significantly with advancing age (25, 57, 57, and 74% and 7, 12, 18, and 31%, respectively, in the 4 age groups [P < .001 and P = .046, respectively]). For subjects receiving NIV with a do-not-intubate order, success and in-hospital mortality rates were similar in different age groups (P = .27 and P = .98, respectively).CONCLUSIONS: NIV use and a do-not-intubate status are more frequent in subjects with ARF ≥65 y than in those <65 y, especially for subjects with cardiogenic pulmonary edema. However, NIV success and mortality rates were similar between age groups. (ClinicalTrials.gov registration NCT00458926.)