RT Journal Article
SR Electronic
T1 Effects of Inspiratory Muscle Training in Subjects With Sarcoidosis: A Randomized Controlled Clinical Trial
JF Respiratory Care
FD American Association for Respiratory Care
SP 483
OP 494
DO 10.4187/respcare.04312
VO 61
IS 4
A1 Karadallı, Müşerrefe Nur
A1 Boşnak-Güçlü, Meral
A1 Camcıoğlu, Burcu
A1 Kokturk, Nurdan
A1 Türktaş, Haluk
YR 2016
UL http://rc.rcjournal.com/content/61/4/483.abstract
AB BACKGROUND: Respiratory muscle weakness occurs in sarcoidosis and is related to decreased exercise capacity, greater fatigue, dyspnea, and lower quality of life in sarcoidosis patients. The effects of inspiratory muscle training in this population have not been comprehensively investigated so far. This study was planned to investigate the effects of inspiratory muscle training on exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life in subjects with sarcoidosis.METHODS: This was a prospective, randomized, controlled, and double blind study. Fifteen sarcoidosis subjects (treatment group) received inspiratory muscle training at 40% of maximal inspiratory pressure (PImax), and 15 subjects (control group) received sham therapy (5% of PImax) for 6 weeks. Functional and maximal exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life were evaluated.RESULTS: Functional (P < .001) and maximal exercise capacity (P = .038), respiratory muscle strength (PImax [P < .001] and PEmax [P = .001]), severe fatigue (P = .002), and dyspnea perception (P = .02) were statistically significantly improved in the treatment group compared with controls; no significant improvements were observed in pulmonary function and diffusing capacity, peripheral muscle strength, fatigue, depression, and quality of life between groups after inspiratory muscle training.CONCLUSIONS: Inspiratory muscle training improves functional and maximal exercise capacity and respiratory muscle strength and decreases severe fatigue and dyspnea perception in subjects with early stages of sarcoidosis. Inspiratory muscle training can be safely and effectively included in rehabilitation programs. (ClinicalTrials.gov registration NCT02270333.)