TY - JOUR T1 - Severe Acute Respiratory Failure Secondary to Acute Fibrinous and Organizing Pneumonia Requiring Mechanical Ventilation: A Case Report and Literature Review JF - Respiratory Care SP - 1337 LP - 1341 DO - 10.4187/respcare.01452 VL - 57 IS - 8 AU - Sonia López-Cuenca AU - Silvia Morales-García AU - Ana Martín-Hita AU - Fernando Frutos-Vivar AU - Pilar Fernández-Segoviano AU - Andrés Esteban Y1 - 2012/08/01 UR - http://rc.rcjournal.com/content/57/8/1337.abstract N2 - A 27-year-old woman was admitted to our ICU with acute hypoxemic respiratory failure and criteria for ARDS. Despite an FIO2 of 1.0 and a lung protective strategy, the patient died on day 15 without any improvement. The relatives gave consent for post-mortem analysis. The histopathologic study of the lung showed findings typical of an acute fibrinous and organizing pneumonia. Apropos of this case we performed a PubMed search. We found 13 articles, including a total of 29 patients. Acute fibrinous and organizing pneumonia is an unusual cause of acute lung injury. The diagnostic criterion is histopathologic. There is little information regarding the pathophysiology of this illness. Important questions remain regarding this disease, including predisposing factors and management. Patients who require mechanical ventilation have poor outcomes. ER -