RT Journal Article SR Electronic T1 Humidified High Flow Nasal Oxygen During Respiratory Failure in the Emergency Department: Feasibility and Efficacy JF Respiratory Care FD American Association for Respiratory Care SP 1873 OP 1878 DO 10.4187/respcare.01575 VO 57 IS 11 A1 Hugo Lenglet A1 Benjamin Sztrymf A1 Christophe Leroy A1 Patrick Brun A1 Didier Dreyfuss A1 Jean-Damien Ricard YR 2012 UL http://rc.rcjournal.com/content/57/11/1873.abstract AB OBJECTIVE: Heated and humidified high flow nasal cannula oxygen therapy (HFNC) represents a new alternative to conventional oxygen therapy that has not been evaluated in the emergency department (ED). We aimed to study its feasibility and efficacy in patients exhibiting acute respiratory failure presenting to the ED. METHODS: Prospective, observational study in a university hospital's ED. Patients with acute respiratory failure requiring > 9 L/min oxygen or with ongoing clinical signs of respiratory distress despite oxygen therapy were included. The device of oxygen administration was then switched from non-rebreathing mask to HFNC. Dyspnea, rated by the Borg scale and a visual analog scale, respiratory rate, and SpO2 were collected before and 15, 30, and 60 min after beginning HFNC. Feasibility was assessed through caregivers' acceptance of the device in terms of practicality and perceived effect on the subjects, evaluated by questionnaire. RESULTS: Seventeen subjects, median age 64 y (46–84.7 y), were studied. Pneumonia was the most common reason for oxygen therapy (n = 9). HFNC was associated with a significant decrease in both dyspnea scores: Borg scale from 6 (5–7) to 3 (2–4) (P < .001), and visual analog scale from 7 (5–8) to 3 (1–5) (P < .01). Respiratory rate decreased from 28 breaths/min (25–32 breaths/min) to 25 breaths/min (21–28 breaths/min) (P < .001), and SpO2 increased from 90% (88.5–94%) to 97% (92.5–100%) (P < .001). Fewer subjects exhibited clinical signs of respiratory distress (10/17 vs 3/17, P = .03). HFNC was well tolerated and no adverse event was noted. Altogether, 76% of healthcare givers declared preferring HFNC, as compared to conventional oxygen therapy. CONCLUSIONS: HFNC is possible in the ED, and it alleviated dyspnea and improved respiratory parameters in subjects with acute hypoxemic respiratory failure.