PT  - JOURNAL ARTICLE
AU  - Meredith C McCormack
TI  - Facing the Noise: Addressing the Endemic Variability in D<sub>LCO</sub> Testing
AID  - 10.4187/respcare.01435
DP  - 2012 Jan 01
TA  - Respiratory Care
PG  - 17--25
VI  - 57
IP  - 1
4099  - http://rc.rcjournal.com/content/57/1/17.short
4100  - http://rc.rcjournal.com/content/57/1/17.full
AB  - Single-breath diffusing capacity of the lung for carbon monoxide (DLCO) is a common pulmonary function test that measures the ability of the lung to exchange gas across the alveolar-capillary interface. DLCO testing is used to narrow the differential diagnosis of obstructive and restrictive lung disease, to aid in disability and transplant assessment, and to monitor medication toxicity. The variability in the measurement limits the utility of the test. Variability is attributable to differences in equipment, testing conditions, patient factors, and reference equations. Laboratories can minimize variability by ensuring that equipment meets recommended standards, implementing effective quality control programs, standardizing testing conditions and testing procedures, and accounting for pertinent patient characteristics.