RT Journal Article
SR Electronic
T1 The Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatment
JF Respiratory Care
FD American Association for Respiratory Care
SP 572
OP 582
DO 10.4187/respcare.01307
VO 57
IS 4
A1 Patrícia Leão da Silva
A1 Marco Túlio de Mello
A1 Nadia Carla Cheik
A1 Priscila Lima Sanches
A1 Aline de Piano
A1 Flávia Campos Corgosinho
A1 Raquel Munhoz da Silveira Campos
A1 June Carnier
A1 Daniela Inoue
A1 Claudia MO do Nascimento
A1 Lila M Oyama
A1 Lian Tock
A1 Sérgio Tufik
A1 Ana R Dâmaso
YR 2012
UL http://rc.rcjournal.com/content/57/4/572.abstract
AB BACKGROUND: Recent studies have demonstrated a greater prevalence in exercise-induced bronchospasm (EIB) in obese adolescents. However, the role of pro-/anti-inflammatory adipokines and the repercussions of obesity treatment on EIB need to be explored further. Therefore, the objective of this study was to evaluate the role of pro-/anti-inflammatory adipokines on EIB in obese adolescents evaluated after long-term interdisciplinary therapy. METHODS: Thirty-five post-pubertal obese adolescents, including 20 non-EIB (body mass index [BMI] 36 ± 5 kg/m2) and 15 EIB (BMI 36 ± 5 kg/m2), were enrolled in this study. Body composition was measured by plethysmography, using the BOD POD body composition system, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin and leptin were analyzed. EIB and lung function were evaluated according to the American Thoracic Society criteria. Patients were recruited to a 1-year interdisciplinary intervention of weight loss, consisting of medical, nutritional, exercise, and psychological components. RESULTS: Anthropometrics and lung function variables improved significantly after the therapy in both groups. Furthermore we observed a reduction in EIB occurrence in obese adolescents after treatment. There was an increase in adiponectin levels and a reduction in leptin levels after the therapy. In addition, a low FEV1 value was a risk factor associated with EIB occurrence at baseline, and was correlated after treatment with changes in anthropometric and maximal O2 consumption values as well as the adipokines profile. CONCLUSIONS: In the present study it was demonstrated that 1 year of interdisciplinary therapy decreased EIB frequency in obese adolescents, paralleled by an increase in lung function and improvement in pro-/anti-inflammatory adipokines.