Review ArticleNew Evidence for Transmitter Role of VIP in The Airways: Impaired Relaxation by a Catalytic Antibody
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2012, Journal of Biological ChemistryCitation Excerpt :Many examples of IgG and IgM class antibodies that catalyze the breakdown of peptide bonds in autoantigens have been reported (1–4). A single catalytic antibody molecule is reused to cleave multiple antigen molecules, and the cleavage reaction often results in permanent inactivation of the antigen (5–7). If combined with the traditional ability to recognize antigenic epitopes with sufficient noncovalent binding affinity, the proteolytic function acquires specificity for individual antigens.
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2008, Autoimmunity ReviewsCitation Excerpt :The protective effects of infusion of IgG from uninfected monkeys against SIV [34] and of pooled IgG from uninfected humans (IVIG) against HIV has been investigated [35]. Proteolytic Igs inactivate antigens irreversibly and with potency superior to conventional Igs [36]. Catalytic salivary IgAs from uninfected humans neutralized primary, R5-dependent clade B and C strains.
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Correspondence to: Sami I. Said, M.D., Pulmonary and Critical Carre Medicine, HSC T17-040, SUNY at Stony Brook, Stony Brook, NY 11794-8172.Tel: 631444-1754; Fax: 631444-7502; E-mail: [email protected]