Abstract
Objective
To compare the health-related quality of life (HR-QOL) in acute respiratory distress syndrome (ARDS) survivors with that in a matched control group of non-ARDS survivors.
Design and setting
Prospective, matched, parallel cohort study, comparing HR-QOL between intensive care unit (ICU) survivors with ARDS and a control group in a tertiary care hospital.
Patients
Between May 1997 and December 2000, all ARDS adult patients of an eight-bed medical/surgical unit of a tertiary care hospital were enrolled and a control group of non-ARDS survivors, matched for severity of disease and for previous health state, was selected. The study included 29 ARDS survivors who answered the EQ-5D questionnaire and had lung function evaluated.
Measurements and results
A follow-up appointment was performed 6 months after ICU discharge consisting of: (a) evaluation of HR-QOL using EQ-5D and (b) lung function tests and measure of diffusing capacity. Among ARDS survivors 41% had normal lung function and 59% mild to moderate lung function impairments. Nearly a one-third of ARDS survivors reported problems in one or more of the five dimensions of the EQ-5D, and 48% reported feeling worse at the interview than 6 month before ICU admission. No significant differences were found in HR-QOL between ARDS survivors and other ICU survivors with similar age and matched for previous health state and severity of disease.
Conclusions
This study suggests that impairments in HR-QOL among ARDS survivors may not be distinguishable from that among other ICU survivors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ware LB, Matthay M (2000) The acute respiratory distress syndrome. N Engl J Med 342:1334–1349
Rocco TR Jr, Reinert SE, Cioffi W, Harrington D, Buczko G, Simms HH (2001) A 9-year, single institution, retrospective review of death rate and prognostic factors in adult respiratory distress syndrome. Ann Surg 233:414–422
McHugh LG, Milberg JA, Whitcomb ME, Schoene RB, Maunder RJ, Hudson LD (1994) Recovery of function in survivors of the acute respiratory distress syndrome. Am J Respir Crit Care Med 150:90–94
Hert R, Albert RK (1994) Sequelae of the adult respiratory distress syndrome. Thorax 49:8–13
Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky A (2003) One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 348:683–693
Schelling G, Stoll C, Haller M, Briegel J, Manert W, Hummel T, Lenhart A, Heyduck M, Polasek J, Preub U, Bullinger M, Schuffel W, Peter K (1998) Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Crit Care Med 26:651–659
Schelling G, Stoll C, Vogelmeier C, Hummel T, Behr J, Kapfhammer HP, Rothenhausler HB, Haller M, Durst K, Krauseneck T, Briegel J (2000) Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome. Intensive Care Med 26:1304–1311
Hopkins RO, Weaver LK, Pope D, Orme JF Jr, Bigler ED, Larson-Lohr V (1999) Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med 160:50–56
Cooper AB, Ferguson ND, Hanly PJ, Meade MO, Kachura JR, Granton JT, Slutsky AS, Stewart TE (1999) Long-term follow-up of survivors of acute lung injury: lack of effect of a ventilation strategy to prevent barotrauma. Crit Care Med 27:2616–2621
Davidson TA, Caldweel ES, Curtis JR, Hudson LD, Steinberg KP (1999) Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill patients. JAMA 281:354–360
Angus DC, Musthafa AA, Clermont G, Griffin MF, Linde-Zwirble WT, Dremsizov TT, Pinsky MR (2001) Quality-adjusted survival in the first year after the acute respiratory distress syndrome. Am J Respir Crit Care Med 163:1389–1394
Hamel MB, Phillips RS, Davis RB, Teno J, Connors AF, Desbiens N, Lynn J, Dawson NV, Fulkerson W, Tsevat J (2000) Outcomes and cost-effectiveness of ventilator support and aggressive care for patients with acute respiratory failure due to pneumonia or acute respiratory distress syndrome. Am J Med 109:614–620
Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R, The Consensus Committee (1994) Report of the American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. Intensive Care Med 20:225–232
EuroQol Group (1990) EuroQol—a new facility for the measurement of health-related quality of life. Health Policy 16:199–208
Brooks R, with the EuroQol Group (1996) EuroQol: the current state of play. Health Policy 37:53–72
Kuilman M, Bleeker JK, Hartman JAM, Simoons ML (1999) Long-term survival after out-of-hospital cardiac arrest: an 8 year follow-up. Resuscitation 41:25–31
Dolan P (1997) Modeling valuations for EuroQol health states. Med Care 35:1095–1108
Granja C, Teixeira-Pinto A, Costa-Pereira A (2002) Quality of life after intensive care—evaluation with EQ-5D. Intensive Care Med 28:898–907
Ely EW, Wheeler AP, Thompson BT, Ancukiewicz M, Steinberg P, Bernard GR for the Acute Respiratory Distress Syndrome Network (2002) Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med 136:25–36
Suchyta MR, Clemmer TP, Elliot CG, Orme Jr JF, Morris AH, Jacobson J, Menlove R (1997) Increased mortality of older patients with acute respiratory distress syndrome. Chest 111:1334–1339
Angus D, Carlet J (2003) Surviving intensive care: a report from the 2002 Brussels Roundtable. Intensive Care Med 29:368–377
Acknowledgements
We thank Alexandra Vieira and Luís Filipe Azevedo for their invaluable help in data management and analysis, and Paula Simão and Paula Negrão for their assistance in lung function evaluation.
Author information
Authors and Affiliations
Corresponding author
Additional information
An editorial regarding this article can be found in the same issue (http://dx.doi.org/10.1007/s00134-003-1855-3)
Rights and permissions
About this article
Cite this article
Granja, C., Morujão, E. & Costa-Pereira, A. Quality of life in acute respiratory distress syndrome survivors may be no worst than in other ICU survivors. Intensive Care Med 29, 1744–1750 (2003). https://doi.org/10.1007/s00134-003-1808-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00134-003-1808-x