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Evaluation of oxidative stress measurements in obstructive sleep apnea syndrome

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Summary.

Assessment of reactive oxygen species (ROS) is highly important in neurodegenerative disorders and neuroleptic treatment. However, conflicting results have been reported, which may arise from methodological difficulties. Obstructive sleep apnea (OSA) syndrome with episodic hypoxia-reoxygenation is proposed as a human model for the investigation of ROS measurements. Despite a broad analytical approach comprising lipid peroxidation and amino acid oxidation products, oxidative DNA damage, and activity of the antioxidant defense, only plasma malondialdehyde (MDA) and urinary o,o′-dityrosine seemed to be appropriate, robust biomarkers of oxidative stress, which are also simple enough for routine clinical use. MDA concentrations correlated with a duration of nocturnal desaturation below 85% (r = 0.77, p<0.0005), and o,o′-dityrosine levels decreased after therapy (p<0.05) as a function of baseline concentrations (r = −0.61, p<0.05). Gender effects in ROS generation also have to be considered. At present, we recommend the application of several oxidative stress measurements at different time points, preferably involving plasma MDA and urinary o,o′-dityrosine.

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References

  • U Abdel-Rahman T Aybek A Moritz P Kleine G Matheis (2003) ArticleTitleGraded reoxygenation limits lipid peroxidation during surgical reperfusion. Med Sci Monit 9 IssueID9 CR389–CR391 Occurrence Handle12960927

    PubMed  Google Scholar 

  • JE Ahlskog RJ Uitti PA Low GM Tyce KK Nickander RC Petersen E Kokmen (1995) ArticleTitleNo evidence for systemic oxidant stress in Parkinson’s or Alzheimer’s disease. Mov Disord 10 IssueID5 566–573 Occurrence Handle10.1002/mds.870100507 Occurrence Handle1:STN:280:BymD28vjt1w%3D Occurrence Handle8552107

    Article  CAS  PubMed  Google Scholar 

  • Ö Akyol H Herken E Uz E Fadillioglu S Ünal S Sögüt H Özyurt HA Savas (2002) ArticleTitleThe indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients. The possible role of oxidant/antioxidant imbalance. Prog Neuropsychopharmacol Biol Psychiatry 26 IssueID5 995–1005 Occurrence Handle10.1016/S0278-5846(02)00220-8 Occurrence Handle1:CAS:528:DC%2BD38XmsVCiuro%3D Occurrence Handle12369276

    Article  CAS  PubMed  Google Scholar 

  • I Altuntas H Aksoy I Coskun A Caykoylu F Akcay (2000) ArticleTitleErythrocyte superoxide dismutase and glutathione peroxidase activities, and malondialdehyde and reduced glutathione levels in schizophrenic patients. Clin Chem Lab Med 38 IssueID12 1277–1281 Occurrence Handle10.1515/CCLM.2000.201 Occurrence Handle1:CAS:528:DC%2BD3MXhsFWhurk%3D Occurrence Handle11205693

    Article  CAS  PubMed  Google Scholar 

  • InstitutionalAuthorNameAmerican Thoracic Society (1989) ArticleTitleIndications and standards for cardiopulmonary sleep studies. Am Rev Respir Dis 139 559–567

    Google Scholar 

  • BN Ames MK Shigenaga TM Hagen (1993) ArticleTitleOxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90 7915–7922 Occurrence Handle1:CAS:528:DyaK3sXmtVSksL4%3D Occurrence Handle8367443

    CAS  PubMed  Google Scholar 

  • G Baydas S Kutlu M Naziroglu S Canpolat S Sandal M Ozcan H Kelestimur (2003) ArticleTitleInhibitory effects of melatonin on neural lipid peroxidation induced by intracerebroventricularly administered homocysteine. J Pineal Res 34 36–39 Occurrence Handle10.1034/j.1600-079X.2003.02939.x Occurrence Handle1:CAS:528:DC%2BD3sXntVGntQ%3D%3D Occurrence Handle12485370

    Article  CAS  PubMed  Google Scholar 

  • FM Benes J Walsh S Bhattacharyya A Sheth S Berretta (2003) ArticleTitleDNA fragmentation decreased in schizophrenia but not bipolar disorder. Arch Gen Psychiatry 60 359–364 Occurrence Handle12695312

    PubMed  Google Scholar 

  • P Bermejo P Gomez-Serranillos J Santos E Pastor P Gil S Martin-Aragon (1997) ArticleTitleDetermination of malonaldehyde in Alzheimer’s disease: a comparative study of high-performance liquid chromatography and thiobarbituric acid test. Gerontology 43 IssueID4 218–222 Occurrence Handle1:CAS:528:DyaK2sXktlGmsLs%3D Occurrence Handle9222750

    CAS  PubMed  Google Scholar 

  • S Bleich K Spilker C Kurth D Degner M Quintela-Schneider K Javaheripour E Rüther J Kornhuber J Wiltfang (2000a) ArticleTitleOxidative stress and an altered methionine metabolism in alcoholism. Neurosci Lett 293 IssueID3 171–174 Occurrence Handle10.1016/S0304-3940(00)01505-6 Occurrence Handle1:CAS:528:DC%2BD3cXosV2hsL0%3D

    Article  CAS  Google Scholar 

  • S Bleich S Kropp D Degner I Zerr J Pilz CH Gleiter M Otto E Rüther HA Kretzschmar J Wiltfang J Kornhuber S Poser (2000b) ArticleTitleCreutzfeldt-Jakob disease and oxidative stress. Acta Neurol Scand 101 IssueID5 332–334 Occurrence Handle10.1034/j.1600-0404.2000.9s290a.x Occurrence Handle1:CAS:528:DC%2BD3cXjslSls70%3D

    Article  CAS  Google Scholar 

  • GE Carpagnano SA Kharitonov O Resta MP Foschino-Barbaro E Gramiccioni PJ Barnes (2003) ArticleTitle8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy. Chest 124 IssueID4 1386–1392 Occurrence Handle10.1378/chest.124.4.1386 Occurrence Handle1:CAS:528:DC%2BD3sXovF2hs7k%3D Occurrence Handle14555570

    Article  CAS  PubMed  Google Scholar 

  • K Christou N Markoulis AN Moulas C Pastaka KI Gourgoulianis (2003) ArticleTitleReactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients. Sleep Breath 7 IssueID3 105–110 Occurrence Handle10.1007/s11325-003-0105-9 Occurrence Handle14569521

    Article  PubMed  Google Scholar 

  • G Dakhale S Khanzode S Khanzode A Saoji L Khobragade A Turankar (2004) ArticleTitleOxidative damage and schizophrenia: the potential benefit by atypical antipsychotics. Neuropsychobiology 49 IssueID4 205–209 Occurrence Handle10.1159/000077368 Occurrence Handle15154399

    Article  PubMed  Google Scholar 

  • EE Dubinina MG Morozova NV Leonova NL Gamper IB Soliternova IL Nuller GB Butoma SV Kovrugina (2000) ArticleTitleOxidative modification of blood proteins in patients with psychiatric disorders (depression, depersonalization). Vopr Med Khim 46 IssueID4 398–409 Occurrence Handle1:CAS:528:DC%2BD3cXotl2gtLo%3D Occurrence Handle11075423

    CAS  PubMed  Google Scholar 

  • SM Freudenthaler K-H Schreeb A Wiese J Pilz CH Gleiter (2002) ArticleTitleInfluence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans. Acta Physiol Scand 174 231–235 Occurrence Handle10.1046/j.1365-201x.2002.00946.x Occurrence Handle1:CAS:528:DC%2BD38XitF2is74%3D Occurrence Handle11906322

    Article  CAS  PubMed  Google Scholar 

  • D Germadnik A Pilger HW Rüdiger (1997) ArticleTitleAssay for the determination of urinary 8-hydroxy-2-deoxyguanosine by high-performance liquid chromatography with electrochemical detection. J Chromatogr B 689 399–403 Occurrence Handle1:CAS:528:DyaK2sXhtlyit7s%3D

    CAS  Google Scholar 

  • B Halliwell (1992) ArticleTitleReactive oxygen species and the central nervous system. J Neurochem 59 1609–1623 Occurrence Handle1:CAS:528:DyaK38XmsVKlsbk%3D Occurrence Handle1402908

    CAS  PubMed  Google Scholar 

  • A Hausen D Fuchs K Konig H Wachter (1982) ArticleTitleDetermination of neopterine in human urine by reversed-phase high-performance liquid chromatography. J Chromatogr 227 IssueID1 61–70 Occurrence Handle1:CAS:528:DyaL38XmsFSqsw%3D%3D Occurrence Handle7056823

    CAS  PubMed  Google Scholar 

  • K Hensley ML Maidt Z Yu H Sang WR Markesbery RA Floyd (1998) ArticleTitleElectrochemical analysis of protein nitrityrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neurosci 18 IssueID20 8126–8132 Occurrence Handle1:CAS:528:DyaK1cXms1ehtL0%3D Occurrence Handle9763459

    CAS  PubMed  Google Scholar 

  • TV Ilic M Jovanovic A Jovicic M Tomovic (1999) ArticleTitleOxidative stress indicators are elevated in de novo Parkinson’s disease patients. Funct Neurol 14 IssueID3 141–147 Occurrence Handle1:STN:280:DC%2BD3c%2FjsVajuw%3D%3D Occurrence Handle10568214

    CAS  PubMed  Google Scholar 

  • M Irie S Asami S Nagata M Miyata H Kasai (2001) ArticleTitleRelationships between perceived workload, stress and oxidative DNA damage. Int Arch Occup Environ Health 74 153–157 Occurrence Handle10.1007/s004200000209 Occurrence Handle1:CAS:528:DC%2BD3MXht1Ols7k%3D Occurrence Handle11317710

    Article  CAS  PubMed  Google Scholar 

  • W Jordan C Berger S Cohrs A Rodenbeck G Mayer PD Niedmann N von Ahsen E Rüther J Kornhuber S Bleich (2004a) ArticleTitleCPAP-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome. J Neural Transm 111 683–689 Occurrence Handle1:CAS:528:DC%2BD2cXksVensbk%3D

    CAS  Google Scholar 

  • W Jordan H Tumani S Cohrs S Eggert A Rodenbeck E Brunner E Rüther G Hajak (2004b) ArticleTitleProstaglandin D synthase (β-trace) in healthy human sleep. Sleep 27 IssueID5 867–874

    Google Scholar 

  • Jordan W, Reinbacher A, Cohrs S, Grunewald RW, Mayer G, Rüther E, Rodenbeck A (2005a) Obstructive sleep apnea: plasma endothelin-1 precursor but not endothelin-1 levels are elevated and decline with nasal continuous positive airway pressure. Peptides (in press)

  • Jordan W, Tumani H, Cohrs S, Rodenbeck A, Rüther E, Bechthold J, Mayer G (2005b) Narcolepsy: increased L-PGDS (β-trace) levels correlate with excessive daytime sleepiness but not with cataplexy. J Neurol (in press)

  • Kropp S, Kern V, Lange K, Degner D, Hajak G, Kornhuber J, Rüther E, Emrich HM, Schneider U, Bleich S (2004) Oxidative stress during treatment with first- and second-generation antipsychotics. J Neuropsychiatry (in press)

  • M Kuloglu B Ustundag M Atmaca H Canatan AE Tezcan N Cinkilinc (2002) ArticleTitleLipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochem Funct 20 171–175 Occurrence Handle10.1002/cbf.940 Occurrence Handle1:CAS:528:DC%2BD38XjvV2mu70%3D Occurrence Handle11979513

    Article  CAS  PubMed  Google Scholar 

  • FRM Laurindo PL da Luz L Uint TF Rocha RG Jaeger EA Lopes (1991) ArticleTitleEvidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. Circulation 83 1705–1715 Occurrence Handle1:CAS:528:DyaK3MXkt1Ojs78%3D Occurrence Handle1850666

    CAS  PubMed  Google Scholar 

  • L Lavie (2003) ArticleTitleObstructive sleep apnoea syndrome – an oxidative stress disorder. Sleep Med Rev 7 IssueID1 35–51 Occurrence Handle10.1053/smrv.2002.0261 Occurrence Handle12586529

    Article  PubMed  Google Scholar 

  • L Lavie A Hefetz R Luboshitzky P Lavie (2003) ArticleTitlePlasma levels of nitric oxide and L-arginine in sleep apnea patients: effects of nCPAP treatment. J Mol Neurosci 21 IssueID1 57–64 Occurrence Handle1:CAS:528:DC%2BD2cXjtFWqu70%3D Occurrence Handle14500996

    CAS  PubMed  Google Scholar 

  • C Leeuwenburgh PA Hansen JO Holloszy JW Heinecke (1999) ArticleTitleOxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo. Am J Physiol 276 IssueID1 Pt 2 R128–R135 Occurrence Handle1:CAS:528:DyaK1MXntlWgtA%3D%3D Occurrence Handle9887186

    CAS  PubMed  Google Scholar 

  • DA Malencik JF Sprouse CA Swanson SR Anderson (1996) ArticleTitleDityrosine: preparation, isolation, and analysis. Anal Biochem 242 IssueID2 202–213 Occurrence Handle10.1006/abio.1996.0454 Occurrence Handle1:CAS:528:DyaK28XntVKgtLs%3D Occurrence Handle8937563

    Article  CAS  PubMed  Google Scholar 

  • MJ Manary C Leeuwenburgh JW Heinecke (2000) ArticleTitleIncreased oxidative stress in kwashiorkor. J Pediatr 137 IssueID3 421–424 Occurrence Handle1:CAS:528:DC%2BD3cXntFChsLc%3D Occurrence Handle10969271

    CAS  PubMed  Google Scholar 

  • M Matsuzaki T Hasegawa A Takeda A Kikuchi K Furukawa Y Kato Y Itoyama (2004) ArticleTitleHistochemical features of stress-induced aggregates in alpha-synuclein overexpressing cells. Brain Res 1004 IssueID1–2 83–90 Occurrence Handle1:CAS:528:DC%2BD2cXitFaqtL4%3D Occurrence Handle15033422

    CAS  PubMed  Google Scholar 

  • P Mecocci U MacGarvey AE Kaufman D Koontz JM Shoffner DC Wallace MF Beal (1993) ArticleTitleOxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 34 609–616 Occurrence Handle10.1002/ana.410340416 Occurrence Handle1:CAS:528:DyaK2cXitFCgsbk%3D Occurrence Handle8215249

    Article  CAS  PubMed  Google Scholar 

  • A Meister (1988) ArticleTitleGlutathione metabolism and its selective modification. J Biol Chem 263 IssueID33 17205–17208 Occurrence Handle1:CAS:528:DyaL1cXmtVKrs7g%3D Occurrence Handle3053703

    CAS  PubMed  Google Scholar 

  • JA Molina FJ Jimenez-Jimenez P Fernandez-Calle L Lalinde JM Tenias M Pondal A Vazquez R Codoceo (1992) ArticleTitleSerum lipid peroxides in patients with Parkinson’s disease. Neurosci Lett 136 IssueID2 137–140 Occurrence Handle10.1016/0304-3940(92)90033-4 Occurrence Handle1:CAS:528:DyaK38XhslWms7k%3D Occurrence Handle1641180

    Article  CAS  PubMed  Google Scholar 

  • Y Ohara TE Peterson DG Harrison (1993) ArticleTitleHypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91 2546–2551 Occurrence Handle1:CAS:528:DyaK3sXltFCru7s%3D Occurrence Handle8390482

    CAS  PubMed  Google Scholar 

  • Y Okatani A Wakatsuki RJ Reiter (2000) ArticleTitleProtective effects of melatonin against homocysteine-induced vasoconstriction of human umbilical artery. Biochem Biophys Res Commun 277 470–475 Occurrence Handle10.1006/bbrc.2000.3687 Occurrence Handle1:CAS:528:DC%2BD3cXntlGitro%3D Occurrence Handle11032746

    Article  CAS  PubMed  Google Scholar 

  • H Orhan NP Vermeulen C Tump H Zappey JH Meerman (2004) ArticleTitleSimultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography-tandem mass spectrometry as non-invasive biomarkers for oxidative damage. J Chromatogr B Analyt Technol Biomed Life Sci 799 IssueID2 245–254 Occurrence Handle1:CAS:528:DC%2BD3sXps1Ogu74%3D Occurrence Handle14670743

    CAS  PubMed  Google Scholar 

  • R Ozcankaya N Delibas (2002) ArticleTitleMalondialdehyde superoxide dismutase, melatonin, iron, copper, and zinc blood concentrations in patients with Alzheimer disease: cross-sectional study. Croat Med J 43 IssueID1 28–32 Occurrence Handle11828555

    PubMed  Google Scholar 

  • S Pennathur V Jackson-Lewis S Przedborski JW Heinecke (1999) ArticleTitleMass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o′-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson’s disease. J Biol Chem 274 IssueID49 34621–34628 Occurrence Handle10.1074/jbc.274.49.34621 Occurrence Handle1:CAS:528:DyaK1MXnvFyrsrs%3D Occurrence Handle10574926

    Article  CAS  PubMed  Google Scholar 

  • J Pilz I Meineke CH Gleiter (2000) ArticleTitleMeasurement of free and bound malondialdehyde in plasma by high-performance liquid chromatography as the 2,4-dinitrophenylhydrazine derivative. J Chromatogr B Biomed Sci Appl 742 IssueID2 315–325 Occurrence Handle10.1016/S0378-4347(00)00174-2 Occurrence Handle1:CAS:528:DC%2BD3cXjslOmu74%3D Occurrence Handle10901136

    Article  CAS  PubMed  Google Scholar 

  • MC Polidori P Mecocci (2002) ArticleTitlePlasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimers Dis 4 IssueID6 517–522 Occurrence Handle1:CAS:528:DC%2BD38Xpsl2ksb0%3D Occurrence Handle12629261

    CAS  PubMed  Google Scholar 

  • A Rechtschaffen A Kales (1968) A manual for standardized terminology, techniques and scoring system for sleep stages of human subjects. Public Health Service, US Government Printing Office Washington DC 1–12

    Google Scholar 

  • R Reddy M Keshavan JK Yao (2003) ArticleTitleReduced plasma antioxidants in first-episode patients with schizophrenia. Schizophr Res 62 205–212 Occurrence Handle10.1016/S0920-9964(02)00407-3 Occurrence Handle12837516

    Article  PubMed  Google Scholar 

  • M Rösler W Retz J Thome P Riederer (1998) ArticleTitleFree radicals in Alzheimer’s dementia: currently available therapeutic strategies. J Neural Transm [Suppl] 54 211–219

    Google Scholar 

  • S Saarelainen T Lehtimaki O Jaak-kola T Poussa M Nikkila T Solakivi MM Nieminen (1999) ArticleTitleAutoantibodies against oxidised low-density lipoprotein in patients with obstructive sleep apnoea. Clin Chem Lab Med 37 IssueID5 517–520 Occurrence Handle10.1515/CCLM.1999.083 Occurrence Handle1:CAS:528:DyaK1MXktVWqtb8%3D Occurrence Handle10418741

    Article  CAS  PubMed  Google Scholar 

  • R Schulz S Mahmoudi K Hattar U Sibelius H Olschewski K Mayer W Seeger F Grimminger (2000) ArticleTitleEnhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy. Am J Respir Crit Care Med 162 IssueID2 Pt 1 566–570 Occurrence Handle1:STN:280:DC%2BD3cvjtlCgsg%3D%3D Occurrence Handle10934088

    CAS  PubMed  Google Scholar 

  • JA Serra RO Dominquez ES de Lustig EM Guareschi AL Famulari EL Bartolome ER Marschoff (2001) ArticleTitleParkinson’s disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson’s, Alzheimer’s and vascular dementia patients. J Neural Transm 108 1135–1148 Occurrence Handle10.1007/s007020170003 Occurrence Handle1:CAS:528:DC%2BD38XjvVSjtg%3D%3D Occurrence Handle11725816

    Article  CAS  PubMed  Google Scholar 

  • C Sierra MA Vilaseca N Brandi R Artuch A Mira M Nieto M Pineda (2001) ArticleTitleOxidative stress in Rett syndrome. Brain Dev 23 IssueID[Suppl1] S236–S239 Occurrence Handle11738881

    PubMed  Google Scholar 

  • NC Smith M Dunnett PC Mills (1995) ArticleTitleSimultaneous quantitation of oxidised and reduced glutathione in equine biological fluids by reversed-phase high-performance liquid chromatography using electrochemical detection. J Chromatogr B Biomed Appl 673 IssueID1 35–41 Occurrence Handle1:CAS:528:DyaK2MXptVegu70%3D Occurrence Handle8925072

    CAS  PubMed  Google Scholar 

  • E Sofic A Rustembegovic G Kroyer G Cao (2002) ArticleTitleSerum antioxidant capacity in neurological, psychiatric, renal diseases and cardiomyopathy. J Neural Transm 109 711–719 Occurrence Handle10.1007/s007020200059 Occurrence Handle1:CAS:528:DC%2BD38XmtVCqsL0%3D Occurrence Handle12111462

    Article  CAS  PubMed  Google Scholar 

  • N Srivastava MK Barthwal PK Dalal AK Agarwal D Nag RC Srimal PK Seth M Dikshit (2001) ArticleTitleNitrite content and antioxidant enzyme levels in the blood of schizophrenia patients. Psychopharmacology 158 140–145 Occurrence Handle10.1007/s002130100860 Occurrence Handle1:CAS:528:DC%2BD3MXpt1Cmu78%3D Occurrence Handle11702087

    Article  CAS  PubMed  Google Scholar 

  • G Tsai DC Goff RW Chang J Flood L Baer JT Coyle (1998) ArticleTitleMarkers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. Am J Psychiatry 155 1207–1213 Occurrence Handle1:STN:280:DyaK1cvgtlKisQ%3D%3D Occurrence Handle9734544

    CAS  PubMed  Google Scholar 

  • SO Wali AS Bahammam H Massaeli GN Pierce N Iliskovic PK Singal MH Kryger (1998) ArticleTitleSusceptibility of LDL to oxidative stress in obstructive sleep apnea. Sleep 21 IssueID3 290–296 Occurrence Handle1:STN:280:DyaK1c3lsl2ksA%3D%3D Occurrence Handle9595608

    CAS  PubMed  Google Scholar 

  • ML Wratten L Sereni C Tetta (2001) ArticleTitleOxidation of albumin is enhanced in the presence of uremic toxins. Ren Fail 23 IssueID3–4 563–571 Occurrence Handle1:CAS:528:DC%2BD3MXmtFequrk%3D Occurrence Handle11499570

    CAS  PubMed  Google Scholar 

  • JK Yao RD Reddy DP van Kammen (2001) ArticleTitleOxidative damage and schizophrenia. An overview of the evidence and its therapeutic implications. CNS Drugs 15 IssueID4 287–310 Occurrence Handle1:CAS:528:DC%2BD3MXjs12nsb0%3D Occurrence Handle11463134

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany

    W. Jordan, S. Cohrs, D. Degner, A. Meier, A. Rodenbeck, J. Pilz & E. Rüther

  2. Hephata Klinik, Schwalmstadt-Treysa, Goettingen, Germany

    G. Mayer

  3. Laboratory of Stress Monitoring, Goettingen, Germany

    J. Pilz

  4. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Germany

    J. Kornhuber & S. Bleich

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Jordan, W., Cohrs, S., Degner, D. et al. Evaluation of oxidative stress measurements in obstructive sleep apnea syndrome. J Neural Transm 113, 239–254 (2006). https://doi.org/10.1007/s00702-005-0316-2

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