Necrotizing sarcoid granulomatosis

doi:10.1016/0007-0971(87)90110-0

British Journal of Diseases of the Chest

Volume 81, 1987, Pages 70-75

https://doi.org/10.1016/0007-0971(87)90110-0 Get rights and content

Abstract

We report a patient with necrotizing sarcoid granulomatosis (NSG) and point out that while the latter may have certain histological and radiological features distinct from sarcoidosis, sophisticated immunological tests show that the two disorders have essentially similar underlying immune mechanisms. We also stress that although the clinical course of NSG has been repeatedly described as benign and responsive to steroid therapy, the young patient may initially be critically ill with symptoms suggestive of an infective process rather than a granulomatous cause.

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The pathogenesis of NSG has not been fully elucidated. Some reports hypothesize that NSG is a subtype of sarcoidosis with vascular inflammation [6–8]. Churg et al. reviewed 12 NSG cases and concluded that the clinical characteristics of NSG are not similar to that of other angiocentric granulomatosis.
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Necrotizing sarcoid granulomatosis is a rare disease of unknown cause that is characterized histologically by the presence of confluent sarcoid-like granulomas associated with variable amounts of parenchymal necrosis and vasculitis.53 Because of some shared similarities in clinical, immunologic, and histologic features, NSG has been postulated to represent a variant of classic sarcoidosis.14,89 Affected patients usually present between the third and seventh decades of life with women more than twice as frequently affected as men.10,14,43,52

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Original articleNecrotizing sarcoid granulomatosis

Abstract

Hum Path

Chest

Lancet

The J. Burns Amberson Lecture—pulmonary angiitis and granulomatosis

Am Rev Resp Dis

Uber generalisiecke Septische Gefassenkrankungen

Verb dt ges Path

Original article
Necrotizing sarcoid granulomatosis