Physical factors determining particle deposition in the human respiratory tract

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Abstract

Total deposition in the human respiratory tract of uncharged, spherical aerosol particles depends on particle diameter, particle density, period of a breathing cycle and respiratory volumetric flow rate. Total deposition of particles larger than 0.5 μm in diameter increases at mouth-breathing with increasing values of these physical factors with the exception that total deposition of particles in the size range between 0.5 and 1 μm is independent of flow rate. These physical factors can be linked by a deposition parameter so that their complex effects on deposition can be described by an unique relationship.

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