Effect of deep inspiration on airway conductance in subjects with allergic rhinitis and allergic asthma☆
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Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma
2020, Pharmacological ResearchCitation Excerpt :The lack of DI benefit is now recognized as a characteristic phenotype of asthma [8]. Regardless of when DIs are taken, either before (bronchoprotection) [9,10] or during bronchoconstriction (bronchodilation) [11,12], the beneficial relaxing effect of DI is mostly absent in asthmatic subjects. Although the exact mechanisms for DI-induced bronchoprotection and bronchodilation in healthy subjects and the lack of such DI effect in asthmatics are still not clear, several theories have been proposed over the years to explain how the lack of bronchodilatory response to DI could contribute to AHR in asthma [8,13].
An in silico study examining the role of airway smooth muscle dynamics and airway compliance on the rate of airway re-narrowing after deep inspiration
2020, Respiratory Physiology and NeurobiologyCitation Excerpt :Asthmatic patients also show limited bronchodilation of constricted airways as compared with non-asthma (Fish et al., 1981; Salome et al., 2003). Fish et al. (1977) in their study of response of patients with asthma and allergic rhinitis (irritation and inflammation of the mucous membrane inside the nose) first suggested that important clues of the mechanism of airway hyperresponsiveness (increased sensitivity of the airways to an inhaled constrictor) may be found in the different response to DI experienced by asthmatics and non-asthmatics. They studied the response of patients to inhaled methacholine (MCh) before and after and showed that asthmatic subjects exhibits greater airway closure than non-asthmatics.
Mechanisms of non-specific airway hyperresponsiveness: Methacholine-induced alterations in airway architecture
2016, Revue des Maladies RespiratoiresRespiratory impedance measurements for assessment of lung mechanics: Focus on asthma
2008, Respiratory Physiology and NeurobiologySpontaneous sigh rates during sedentary activity: Watching television vs reading
2005, Annals of Allergy, Asthma and ImmunologyDeep inspiration and airway smooth muscle adaptation to length change
2003, Respiratory Physiology and Neurobiology
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Supported by grants from the Chicago Lung Association and by National Institutes of Health Pulmonary Young Investigator Award No. 1R23HL19577-01 (Dr. Fish).
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Recipient of the Edward L. Trudeau Fellowship Award of the American Lung Association.