Clinical pharmacology of corticosteroids in bronchial asthma
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Insight into glucocorticoids glucosylation by glucosyltransferase: A combined experimental and in-silico approach
2022, Biophysical ChemistryCitation Excerpt :Prednisone has anti-inflammatory and immunosuppressive effects. It is used to treat conditions such as asthma, rheumatologic diseases, and hypercalcemia associated with malignancy and adrenal insufficiency [13–15]. Cortisone is a synthetic corticosteroid with a structure closely related to cortisol.
Impact of inhaled corticosteroid-induced oropharyngeal adverse events: Results from a meta-analysis
2007, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :Additional nonmedical interventions that may help reduce oropharyngeal adverse events include mouth washing and use of a spacer device. Mouth washing can help remove any ICS deposited after inhalation, especially with DPI formulations, thereby potentially reducing the risk of oropharyngeal adverse events.58-60 However, this activity may not always be practical and can complicate dosing regimens, which may negatively affect adherence to treatment.
Skin manifestations of inhaled corticosteroids in COPD patients: Results from Lung Health Study II
2004, ChestCitation Excerpt :Similarly, in the present analysis of data concerning bruising among participants in the ancillary study of BMD,4 we could find no evidence of an association between BMD loss and easy bruising as a systemic complication of ICS use. While impaired wound healing is a well-known complication of systemic corticosteroid use, the slow healing of skin lesions (“cuts and sores”) has not been reported previously among the complications associated with high-dose ICSs.92223242526 The observation of a significant association between assignment to receive inhaled TAA and the reported slow healing of skin lesions, especially among participants with good inhaler compliance, is a novel finding of the present study.
Prevalence of Esophageal Candidiasis Among Patients Treated With Inhaled Fluticasone Propionate
2003, American Journal of GastroenterologyCitation Excerpt :In this study we found that the prevalence of esophageal candidiasis in patients receiving inhaled FP was significantly higher than in the control patients, thus confirming our initial impression. The putative mechanisms by which inhaled corticosteroids induce esophageal candidiasis have not been fully clarified, but it seems reasonable to speculate that the immunosuppressive and anti-inflammatory effects of corticosteroids play a major role in its pathogenesis (13). Interestingly, we found in our study that all five patients with diabetes mellitus who were treated with inhaled FP had esophageal candidiasis.
Oral candidiasis associated with inhaled corticosteroid use: Comparison of fluticasone and beclomethasone
2003, Annals of Allergy, Asthma and Immunology