Case report
Cystic Adenomatoid Malformation of the Lung Presenting in Adulthood

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Abstract

Cystic adenomatoid malformation is an uncommon embryonic developmental abnormality usually diagnosed in neonates and infants. Its presentation in adulthood is rare, with only 27 cases reported up to now. Due to its rarity, it is seldom suspected and adult physicians are not familiar with its clinical and radiologic features. We report two cases of cystic adenomatoid malformation presenting in adults, one as a recurrent pneumonia, and another as a coincidental finding on a chest roentgenogram. We describe the clinical features, radiologic and computed tomographic findings, and the histopathologic characteristics in this article, along with a review of the literature.

Section snippets

Patient 1

A 46-year-old woman was admitted to our hospital because of community-acquired left lower lobe pneumonia. Her medical history included a left lower lobe pneumonia episode 7 years earlier and a 10-pack-year history of smoking. No previous chest roentgenograms were available. The patient had fever and left pleuritic pain. On physical examination, a few crackles were heard over the lower third of the left lung without other findings. Laboratory tests showed leukocytosis with left shift and were

Comment

Cystic adenomatoid malformation is an uncommon, nonhereditary bronchopulmonary malformation of unknown cause, which results in an arrest in lung development at an early stage. Cystic adenomatoid malformation is usually unilateral, affecting either lung equally, and unilobar with no clear lobar predominance. Stocker and colleagues [1] classified CAM into three different histologic types, which are believed to be determined by the timing of the lung injury during embryologic life. The most

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