Effects of exogenous surfactant therapy on dynamic compliance during mechanical breathing in preterm infants with hyaline membrane disease
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Exogenous surfactant therapy
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2017, Assisted Ventilation of the Neonate: An Evidence-Based Approach to Newborn Respiratory Care: Sixth EditionEffect of Minimally Invasive Surfactant Therapy on Lung Volume and Ventilation in Preterm Infants
2016, Journal of PediatricsCitation Excerpt :The effect of surfactant administration via an endotracheal tube during both conventional and high-frequency ventilation on EELV has been studied extensively in preterm infants. Surfactant increases EELV and, furthermore, this effect is most prominent in the dependent lung regions, suggesting a gravity-dependent distribution15,23; however, there are fundamental differences between MIST and surfactant treatment during mechanical ventilation, such as a slower rate of surfactant infusion and the absence of positive pressure inflations during MIST, which may impact surfactant distribution and its effect on EELV.24 The present study shows that MIST also leads to an increase in EELV, starting at the time of surfactant infusion and stabilization within 5 minutes after administration.
Pharmacologic Adjuncts II. Exogenous Surfactants
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