Elsevier

The Journal of Pediatrics

Volume 115, Issue 3, September 1989, Pages 456-459
The Journal of Pediatrics

Hypoxic airway constriction in infants of very low birth weight recovering from moderate to severe bronchopulmonary dysplasia*

https://doi.org/10.1016/S0022-3476(89)80855-8Get rights and content

We hypothesized that infants recovering from severe bronchopulmonary dysplasia have airway constriction that is, at least in part, related to borderline hypoxia. If this hypothesis were correct, pulmonary resistance should decrease with the administration of oxygen. To test this hypothesis, we studied 10 infants recovering from severe bronchopulmonary dysplasia (study weight 2490 ± 275 gm; birth weight 1010 ± 89 gm; postnatal age 73 ± 7 days; poslconceptional age 38.5 ± 1.6 weeks) and 10 matched control infants (study weight 2430 ± 179 gm; birth weight 2320 ± 195 gm; postnatal age 25 ± 4 days; postconceptional age 37.5 ± 0.8 weeks). Resistance and compliance were measured by means of a mask with a flowmeter and an esophageal balloon (with the PEDS computer program). Measurements in both groups were made in qulet sleep, without sedation, during the inhalation of room air and during the fifth minute of oxygen inhalation. We found that (1) total pulmonary resistance, significantly higher in infants with bronchopulmonary dysplasia than in control infants, decreased from 206.1 ± 47 cm H2O · L−1 · sec−1 during inhalation of room air to 106.5 ± 20.9 during inhalation of 100% oxygen (p<0.05) and (2) pulmonary dynamic compliance, lower in infants with bronchopulmonary dysplasia than in control infants, increased significantly with the administration of 100% oxygen. The results suggest that infants with bronchopulmonary dysplasia have airway constriction and that this is alleviated by inhalation of oxygen.

References (14)

There are more references available in the full text version of this article.

Cited by (88)

  • Sleep-related hypoxemia in children

    2023, Snoring and Obstructive Sleep Apnea in Children
  • Targeting Arterial Oxygen Saturation by Closed-Loop Control of Inspired Oxygen in Preterm Infants

    2019, Clinics in Perinatology
    Citation Excerpt :

    Although essential for avoiding the deleterious effects of hypoxia,1–3 excessive arterial oxygen levels have been associated with eye, lung, and central nervous system (CNS) damage.4–9 More recently, clinical trials have shown increased mortality with exposure to lower saturation ranges10,11 and detrimental pulmonary and hemodynamic effects associated with insufficient oxygenation.12–16 Of greater concern is the reported association between exposure to prolonged episodes of intermittent hypoxemia (IH) and neurodevelopmental impairment.17

  • Oxygenation Instability in the Premature Infant

    2018, The Newborn Lung: Neonatology Questions and Controversies, Third Edition
  • Neonatal Respiratory Therapy

    2018, Avery's Diseases of the Newborn: Tenth Edition
View all citing articles on Scopus
*

Supported by the Medical Research Council of Canada, grant No. MT-4980, The Children's Hospital of Winnipeg Research Foundation, and The Manitoba Health Research Council.

View full text