Case reportThe use of ketamine for the emergency intubation of patients with status asthmaticus
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Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy
2019, Clinical TherapeuticsCitation Excerpt :These unique pharmacokinetic and pharmacodynamic properties make ketamine a useful agent for the initial management of severe asthma exacerbations that require intubation. In cases where patients present with severe asthma exacerbations unresponsive to conventional therapy that require emergency intubation, ketamine was reported to improve clinical and laboratory values after repeated administration.12–14 Infusion doses associated with efficacy ranged from 0.75 to 3 mg/kg/h.13–15 These reports may suggest a dose-dependent bronchodilatory response often not seen with subanesthetic doses used in acute pain management.
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