Clinical lung and heart/lung transplantationAlbuterol Improves Impaired Mucociliary Clearance After Lung Transplantation
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Transplant Patients
This study was approved by The Johns Hopkins Institutional Review Board. Between July 2001 and March 2003, 30 patients were transplanted at The Johns Hopkins Hospital for standard indications. Seven patients agreed to participate in the study by giving their informed consent.
Healthy Volunteers
MCC was also measured in four healthy volunteers who had no symptoms or history of respiratory disease. MCC in this population was compared with MCC measured in the lung transplant patients. We chose to make this comparison
Demographics
The demographics of the seven transplant patients studied are shown in Table 1. There were four male and three female patients, ranging in age from 29 to 61 years at the time of transplant. The average age was 53 ± 11 years.
Single-lung transplantation (SLT) was performed in five patients with chronic obstructive pulmonary disease and in one patient with α1-anti-trypsin deficiency. Three patients received a right lung at transplantation and three patients received a left lung. One subject
Discussion
Results from this study go beyond previous studies, which reported decreased MCC in lung transplant patients at 6 to 19 months after surgery.9, 10 Our study demonstrates that MCC is most likely impaired within 3 months after lung transplantation in the majority of patients. Although MCC was impaired in the allograft, we found that the secondary lung defense mechanism of CC was not affected by transplantation.
The etiology of the diminished MCC observed after lung transplantation is unknown, but
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Supported by The Johns Hopkins Comprehensive Transplant Center and The Johns Hopkins University School of Medicine General Clinical Research Center (NIH/NCRR Grant M01RR00052).