Quarterly Focus Issue: Heart FailureClinical ResearchOscillatory Breathing and Exercise Gas Exchange Abnormalities Prognosticate Early Mortality and Morbidity in Heart Failure
Clinical Research
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Key Words
heart failure
cardiopulmonary exercise testing
oscillatory breathing
early death
gas exchange
Abbreviations and Acronyms
AT
anaerobic threshold
AUC
area under the receiver-operating characteristic curve
BVP
biventricular pacing
CHF
chronic heart failure
CPX
cardiopulmonary exercise testing
CRT
cardiac resynchronization therapy
OB
oscillatory breathing pattern
OR
odds ratio
%pred
percent of predicted value
V̇co2
carbon dioxide output per minute (0°C, 760 mm Hg, dry)
V̇e
minute ventilation (body temperature, ambient atmospheric pressure, saturated with water vapor)
V̇o2
oxygen uptake per minute (0°C, 760 mm Hg, dry)
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The 3 investigators from Harbor-UCLA Medical Center served as the core laboratory for analysis of the exercise physiology of left ventricular heart failure due to systolic dysfunction used in 2 St. Jude Medical (St. Paul, Minnesota) clinical trials (Resynchronization for Hemodynamic Treatment for Heart Failure Management and Cardiac Resynchronization Therapy in Patients With Heart Failure and Narrow QRS Complexes). All authors received funding from St. Jude Medical. However, this study does not have any direct financial support from St. Jude Medical.
Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.