Asthma and lower airway diseaseAsthma control, adiposity, and adipokines among inner-city adolescents
Section snippets
Study design and population
The Asthma Adiposity Study included 368 adolescents 12 to 20 years of age enrolled from among ACE study participants in 10 major urban areas of the United States. All appropriate institutional review boards approved this study. Written informed consent and assent were obtained. The ACE study was a randomized, double-blind, parallel-group trial with a 3-week run-in period to characterize participants, establish treatment, and evaluate adherence.37 The main objective of the ACE study was to
Results
The average age of the Asthma Adiposity Study participants was 14.2 (± 2.0) years, and slightly more than half were male (54.1%). Nearly two thirds were African American (62.5%), and the remainder were predominantly Hispanic (22.6%). Family income levels were low, with approximately 50% having incomes of less than $15,000 per year. Because most research investigations have found effects of obesity to differ between male and female subjects, the initial characteristics table (Table I) presents
Discussion
In this study of inner-city adolescents with asthma, we have provided an extensive analysis of the relationship between obesity and asthma morbidity using a prospective, well-characterized, and closely monitored cohort. Our major finding is that, as in the case between asthma prevalence and obesity,19, 20 sex has substantial influence on the relationship of adiposity to asthma morbidity. In female adolescents only, increased BMI and body fat were associated with worse asthma control, more
References (66)
- et al.
Weight loss and asthma control in severely obese asthmatic females
Respir Med
(2008) - et al.
Higher BMI is associated with worse asthma control and quality of life but not asthma severity
Respir Med
(2006) - et al.
Body mass index and asthma severity among adults presenting to the emergency department
Chest
(2003) - et al.
Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients?
Respir Med
(2005) - et al.
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
Biochem Biophys Res Commun
(1999) - et al.
Sex specificity of asthma associated with objectively measured body mass index and waist circumference: the Humboldt study
Chest
(2005) - et al.
Obesity and adult asthma: potential effect modification by gender, but not by hay fever
Ann Epidemiol
(2008) - et al.
Body mass index and the risk of asthma in adults
Respir Med
(2004) - et al.
Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
Lancet
(2008) - et al.
Adiponectin differentially regulates cytokines in porcine macrophages
Biochem Biophys Res Commun
(2004)
Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
J Allergy Clin Immunol
Prognostic factors of asthma severity: a 9-year international prospective cohort study
J Allergy Clin Immunol
Relationship of body mass index with asthma indicators in head start children
Ann Allergy Asthma Immunol
Does higher body mass index contribute to worse asthma control in an urban population?
J Allergy Clin Immunol
Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma
Respir Med
Body mass index and response to emergency department treatment in adults with severe asthma exacerbations: a prospective cohort study
Chest
Obesity and asthma
Paediatr Respir Rev
Adiposity, asthma, and airway inflammation
J Allergy Clin Immunol
Trends in the association of poverty with overweight among US adolescents, 1971-2004
JAMA
High body mass index for age among US children and adolescents, 2003-2006
JAMA
Prevalence of overweight and obesity in the United States, 1999-2004
JAMA
Prospective study of body mass index, weight change, and risk of adult-onset asthma in women
Arch Intern Med
Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies
Am J Respir Crit Care Med
Body-mass index as a predictor of incident asthma in a prospective cohort of children
Pediatr Pulmonol
Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study
BMJ
Do obese inner-city children with asthma have more symptoms than nonobese children with asthma?
Pediatrics
Asthma and obesity in adolescents: is there an association?
J Asthma
The relationship between obesity and asthma severity and control in adults
J Allergy Clin Immunol
Relationship between asthma severity and obesity
J Asthma
Are overweight asthmatics more difficult to control?
Allergy
Body mass index and asthma severity in the National Asthma Survey
Thorax
Asthma severity is associated with body mass index and early menarche in women
Am J Respir Crit Care Med
Sex differences in asthma morbidity associated with obesity in a representative population sample
J Allergy Clin Immunol
Cited by (165)
Pediatric obesity and severe asthma: Targeting pathways driving inflammation
2023, Pharmacological ResearchObesity and asthma
2022, Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular DiseasePediatric Inner-City Asthma
2021, Immunology and Allergy Clinics of North AmericaTrajectories of adiposity indicators and association with asthma and lung function in urban minority children
2021, Journal of Allergy and Clinical ImmunologyPediatric Inner-City Asthma
2019, Pediatric Clinics of North AmericaAdipokines in adolescence; the associations with lung function and atopy – A cross-sectional study
2020, Respiratory Medicine
This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under contract numbers NO1-AI-25496 and NO1-JAI-25482 and from the National Center for Research Resources, National Institutes of Health, under grants RR00052, M01RR00533, M01RR00071, 5UL1RR024992-02, and 5M01RR020359-04.
Disclosure of potential conflict of interest: J. Kumar has received research support from the National Heart, Lung, and Blood Institute; is President of the Illinois Society of Allergy, Asthma, and Immunology; and is a member of the American Thoracic Society. G. R. Bloomberg has received research support from the National Institutes of Health/National Institute of Allergy and Infectious Diseases. H. Mitchell has received research support from the National Institutes of Health/National Institute of Allergy and Infectious Diseases. C. M. Kercsmar is on the Speakers' Bureau for Merck; and has received research support from Sepracor. E. Matsui has received research support from the National Institutes of Health. S. Steinback has received research support from the National Institutes of Health/National Institute of Allergy and Infectious Diseases; and has served as an expert witness on the topic of bronchiolitis. S. J. Szefler is a Consultant for GlaxoSmithKline, Genentech, Merck, Boeringher-Ingelheim, Novartis, and Schering Plough; has received research support from the NIH/NHLBI Childhood Management Program (CAMP), NHLBI Childhood Asthma Research and Education (CARE), NIH/NHLBI Asthma Clin Res Network (ACRN), NIH/NIAID Inner City Asthma Consortium (ICAC), GlaxoSmithKline, NJH/NHLBI Asthma Net, and NEEHS/EPA Childhood Environmental Health Center Grant. C. A. Sorkness is on the Advisory Board for GlaxoSmithKline, Schering Plough, AstraZeneca, and Novartis; and has received research support from Schering Plough and Sanofi. W. J. Morgan is a consultant for, and Chair of the Data Safety Monitoring Board for the Cystic Fibrosis Foundation; is a Consultant and Chair of the North American Scientific Advisory Group for the Epidemiologic Study of Cystic Fibrosis for Genentech; is a Consultant for Novartis; has received research support from the NIH/University of Wisconsin and Novartis. S. J. Teach has received research support from Novartis; has served as an expert witness on the topics of wheezing, pneumonia, and dehydration; and is a volunteer for the NIAID Food Allergy Guidelines. V. N. Gan has received research support from Baylor College of Medicine/Texas Department of State Health Services. The other authors declare they have no conflicts of interest.