Asthma and lower airway diseaseRelating small airways to asthma control by using impulse oscillometry in children
Section snippets
Study participants
Children aged 6 to 17 years who were being actively treated for asthma on the Children’s Hospital of Orange County Breathmobile were enrolled in the study. The Breathmobile is a mobile asthma clinic that travels to schools, community clinics, and child development centers in low-income neighborhoods throughout Orange County, California, and provides comprehensive asthma care to children who have or are at risk for asthma. Children were included in the study if they were 6 to 17 years of age and
Study sample
Fourteen healthy control subjects and 107 asthmatic subjects were consented for the study. One hundred one (94%) of the asthmatic subjects were able to perform acceptable IOS maneuvers; 6 patients were excluded from the study because their IOS measurements had coherence lower than the recommended values. On the basis of a physician’s assessment, 57 (56%) of the 101 asthmatic subjects had controlled asthma and 44 (44%) had uncontrolled asthma. The demographics of the 3 asthma groups are
Discussion
Our study compared IOS indices of small- and large-airway resistance and reactance in children with controlled and uncontrolled asthma and established cut points to identify uncontrolled asthma. Prebronchodilator (or baseline) values for small-airway resistance (R5-R20) and reactance (AX) performed best, resulting in sensitivities, specificities, positive predictive values, and negative predictive values that all exceeded 0.80. To our knowledge, this is the first study to investigate the
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Supported by National Institutes of Health grant HL070645.
Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.