Asthma and lower airway diseasePeripheral airway impairment measured by oscillometry predicts loss of asthma control in children
Section snippets
Methods
Children aged 7 to 17 years who were being actively treated for asthma by the Children’s Hospital of Orange County Breathmobile were enrolled in the study. The Breathmobile is a mobile asthma clinic that travels to schools in low-income neighborhoods throughout Orange County, California, and provides comprehensive asthma care to children. Children were included if they had a physician’s clinical diagnosis of mild-to-moderate asthma that was controlled according to the guidelines published by
Results
Fifty-four children with controlled asthma were consented for the study at the initial visit. On the basis of physicians’ assessments, 38 (70%) of these subjects continued to have controlled asthma, and 16 (30%) of these subjects lost asthma control on their follow-up visit. The demographics of the 2 groups are presented (Table I). The majority of our study population identified themselves as of Mexican descent, and the rest were a mixed ethnic population primarily of Caucasian and Asian
Discussion
Our study demonstrates that peripheral airway obstruction, as measured by IOS in a field clinical setting, was associated with future loss of asthma control in a pediatric population. Although asthma control was assessed by the physician independently of IOS, the cut points of peripheral airway IOS indices, including R5-20 and AX, were able to correctly classify up to 91% of our population. These findings suggest that IOS indices of peripheral airway function are useful in identifying asthmatic
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Supported by National Institutes of Health grant HL070645.
Disclosure of potential conflict of interest: S. P. Galant has received research support from the University of California, Irvine. The rest of the authors declare that they have no relevant conflicts of interest.