Original ArticleSex Differences in Habitual Physical Activity and Lung Function Decline in Children with Cystic Fibrosis
Section snippets
Subject Selection
Patients 7 to 17 years of age who had reported participating in their “typical habitual” activity during the past week were recruited from the HSC and Montreal Children's Hospital (MCH) CF clinics. Children arriving at the clinic unwell, displaying symptoms such as an increased cough, purulent sputum, malaise, fever, and/or inability to participate in regular habitual physical activity, were recruited at a later visit. The Research Ethics Boards of HSC and MCH approved the study protocol, and
Results
Of the 153 eligible children from the HSC and MCH CF clinics who were approached to participate in the study, 116 agreed to participate (n = 103 HSC; n = 13 MCH). Reasons for nonparticipation included enrollment in other studies, irregularity of visits to the clinic, inadequate cognitive function, or lack of interest.
Since mean values and frequencies of baseline characteristics such as sex, initial FEV1, and age were found to be comparable in the two centers, all analyses are reported for the
Discussion
This longitudinal study investigated the relation between habitual activity and lung function decline in children with CF. Mixed-model regression analysis showed that the rate of decline of FEV1 was related to the level of habitual physical activity in girls but not in boys. Female subjects in the lower two activity quartiles (Q1, Q2) were characterized by much steeper rates of decline than those in Q3 and Q4. This relation of FEV1 and activity quartile persisted even when the quartiles were
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