Original ArticleCerebral Oxygenation, Extraction, and Autoregulation in Very Preterm Infants Who Develop Peri-Intraventricular Hemorrhage
Section snippets
Methods
This study is a subanalysis of a prospective observational study of all infants admitted to the neonatal intensive care unit of Wilhelmina Children's Hospital with a gestational age of ≤32 completed weeks. The study was approved by the Medical Ethical Committee of the University Medical Center Utrecht. Parental informed consent was obtained for all infants.
Continuous data on rScO2 and cFTOE captured by NIRS during the first 72 hours of life were collected prospectively.10, 13, 14 These data
Results
The clinical characteristics of the mild-moderate and severe PIVH groups are summarized in Table I. Analyzing all PIVH cases together showed that only the inotropics score was significantly higher in cases than controls (median, 3 [range, 0-5] vs 0 [0-5]; P < .001). For the 30 cases, the mean interval between the most recent cUS examination without PIVH and the first cUS examination with PIVH was 21 hours (range, 3-36 hours).
Five infants had grade I PIVH, 14 had grade II PIVH, 6 had grade III
Discussion
Higher rScO2 and lower cFTOE values suggest increased perfusion before the development of severe PIVH.23 These higher rScO2 values were not caused by higher SaO2 values (Table II). This is substantiated by cFTOE values moving in the opposite direction. Moreover, Naulaers et al14 showed that cerebral oxygenation during the first 3 days of life in very preterm infants had no association with SaO2 as long as SaO2 remained stable. Our data on MABP–rScO2 correlation suggest that (prolonged) blood
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The authors declare no conflicts of interest.