Abstract
A metered-dose powder inhaler system has been developed. It is a multidose system that is easy to load and handle for the patient and that does not demand coordination between activation and inhalation. In addition, the new inhaler system is free of propellants, carriers, and other drug additives. Terbutaline sulfate has been selected as a suitable compound for evaluation of this inhaler. Clinical tests with the Turbuhaler have been performed and it has been compared with the conventional terbutaline pressurized metered-dose inhaler (MDI). The new powder inhaler can even be used at low inspiratory flow rates such as those present during acute asthma attacks.
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REFERENCES
S. P. Newman and S. W. Clarke. In F. Morén, M.T. Newhouse, and M. B. Dolovich (eds.), Aerosols in Medicine, Principles, Diagnosis and Therapy, Elsevier, Amsterdam, 1985, pp. 289–312.
J. Yarbrough, L. E. Mansfield, and S. Ting. Ann. Allergy 55:25–27 (1985).
G. K. Crompton. Eur. J. Resp. Dis. (Suppl. 119) 63:101–104 (1982).
J. O. Warner and P. Chetcuti. In S. P. Newman, F. Morén, and G. K. Crompton (eds.), A New Concept in Inhalation Therapy, Proceedings of an International Workshop on a New Inhaler, May 21–22, 1987, London, U.K. Medicom (ISBN 90 5139 004-1), London, 1987, pp. 166–172.
S. Pedersen. In S. P. Newman, F. Morén, and G. K. Crompton (eds.), A New Concept in Inhalation Therapy, Proceedings of an International Workshop on a New Inhaler, May 21–22, 1987, London, U.K. Medicom (ISBN 90 5139 004-1), London, 1987, pp. 146–150.
J. H. Bell, P. S. Hartley, and J. S. G. Cox. J. Pharm. Sci. 60:1559–1564 (1971).
N.-I. M. Kjellman and B. Wirenstrand. Allergy 36:437–438 (1981).
F. Morén. In F. Morén, M. T. Newhouse, and M. B. Dolovich (eds.), Aerosols in Medicine, Principles, Diagnosis and Therapy, Elsevier, Amsterdam, 1985, pp. 261–287.
K. I. L. Wetterlin. U.S. patent 4524769 (1985).
R. Virtanen. Swedish patent application 8501806-7 (1985).
K. I. L. Wetterlin, R. Virtanen, and J. A. R. Andersson. Swedish patent application 8601060-0 (1986).
H. Jaegfeldt, J. A. R. Andersson, E. Trofast, and K. I. L. Wetterlin. In S. P. Newman, F. Morén, and G. K. Crompton (eds.), A New Concept in Inhalation Therapy, Proceedings of an International Workshop on a New Inhaler, May 21–22, 1987, London, U.K. Medicom (ISBN 90 5139 004-1), London, 1987, pp. 90–99.
S. P. Newman and D. Pavia. In F. Morén, M. T. Newhouse, and M. B. Dolovich (eds.), Aerosols in Medicine, Principles, Diagnosis and Therapy, Elsevier, Amsterdam, 1985, pp. 193–217.
J. E. Wirén, G. Eklundh, and G. B. Persson. XVI Nordiske Allergologiske Kongress, Tromsö, June 17–20, 1987.
K. Osterman and A.-M. Norborg. In S. P. Newman, F. Morén, and G. K. Crompton (eds.), A New Concept in Inhalation Therapy, Proceedings of an International Workshop on a New Inhaler, May 21–22, 1987, London, U.K. Medicom (ISBN 90 5139 004-1), London, 1987, pp. 158–165.
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Wetterlin, K. Turbuhaler: A New Powder Inhaler for Administration of Drugs to the Airways. Pharm Res 5, 506–508 (1988). https://doi.org/10.1023/A:1015969324799
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DOI: https://doi.org/10.1023/A:1015969324799