Case ReportsInflammatory myofibroblastic tumor presenting with tracheal obstruction in a pregnant woman*
Section snippets
Terminology
Inflammatory myofibroblastic tumor (or IMT) is a controversial entity. Its name evolved from the term inflammatory pseudotumor, which originally was used to describe an apparent pseudosarcomatous proliferation of the lung. The term IMT came into use once the major component of spindle-shaped myofibroblasts became apparent and cytogenetic studies pointed to a neoplastic rather than inflammatory origin.2
Further contributing to the controversy surrounding IMT is the preponderance of tumors in
Conclusion
Inflammatory myofibroblastic tumor is a controversial entity, whose name evolved from further characterization of the inflammatory pseudotumor or plasma cell granuloma of the lung. It is considered a benign, but possibly neoplastic tumor; it is closely related to inflammatory fibrosarcoma and can therefore be locally recurrent.
IMT occurs most commonly in the lung and in children. However, multiple head and neck cases have been documented, and it may occasionally present with airway obstruction
References (20)
Two interesting benign lung tumors of contradictory histopathology; Remarks on the necessity for maintaining a chest tumor registry
J Thorac Surg
(1939)- et al.
Granular cell tumour in a child's trachea—A diagnostic and therapeutic challenge
Int J Pediatr Otorhinol
(1994) The laryngeal mask airway—A new concept in airway management
Br J Anaesth
(1983)- et al.
Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases
Am J Surg Pathol
(1995) - et al.
Inflammatory myofibroblastic tumor (plasma cell granuloma): Clincopathologic study of 20 cases with immunohistochemical and ultracstructural observations
Am J Clin Pathol
(1990) - et al.
Inflammatory fibrosarcoma of the mesentery and retroperitoneum: A tumor closely simulating inflammatory pseudotumor
Am J Surg Pathol
(1991) - et al.
Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: An historical review with differential diagnostic considerations
Semin Diagn Pathol
(1998) - et al.
Inflammatory pseudotumor: What is it? How does it behave?
Ann Otol Rhinol Laryngol
(1995) - et al.
Postinflammatory “tumors” of the lung
J Thorac Surg
(1954) - et al.
Inflammatory myofibroblastic tumors of the larynx: A clincopathologic study of eight cases simulating a malignant spindle cell neoplasm
Cancer
(1995)
Cited by (27)
Managment of head and neck cancers during pregnancy
2011, Otolaryngologia PolskaMalignant transformation of tracheal inflammatory pseudotumor: A case report
2009, Journal of Thoracic and Cardiovascular SurgeryCitation Excerpt :Difficult cases such as infantile myofibromatosis and rhabdomyosarcoma can be excluded using IHC stains with careful morphologic assessment. Cytokeratin stain, S-100 stain, and HMB45 stain are negative in IPTs.3 The local recurrences, distant metastases, clonal chromosomal aberrations, and even sarcomatous progression described in a few reported cases suggest the malignant potential of IPTs.5
Intradural cervical inflammatory pseudotumor mimicking epidural hematoma in a pregnant woman: case report and review of the literature
2008, Surgical NeurologyCitation Excerpt :No inciting factor could be determined in our patient. There is no evidence of documented IPT association with pregnancy; the very few reported cases of IPT in pregnant women [2,21] do not allow any further conclusions concerning the pregnancy implication in the IPT pathogenesis process. In most cases, IPTs are not formally diagnosed until the excised mass is examined histologically and subjected to immunologic staining techniques.
Management principles of head and neck cancers during pregnancy: A review and case series
2008, Oral OncologyCitation Excerpt :Those, which do not resolve may be excised post-partum, after they have organised, to minimise bleeding.34 Clearly, other benign tumours may present during pregnancy, granular cell tumour35 and inflammatory myofibroblastic tumour36 of the trachea, desmoid tumour37 and paraganglioma38 of the larynx, ectopic lingual thyroid,39 and a case of nasopharyngeal angiofibroma40 have all been reported. For any tumour mass it is essential to make an accurate diagnosis to achieve a correct and successful outcome.
Pulmonary Processes of Indeterminate Malignant Potential
2008, Pulmonary Pathology: a Volume in the Series Foundations in Diagnostic PathologyMyofibroblastic inflammatory tumor of the lung: CT findings with pathologic correlation
2007, Computerized Medical Imaging and Graphics
- *
Address correspondence to Roy Amir, MD, Department of Otolaryngology—Head and Neck Surgery, University of Illinois at Chicago, 1855 W Taylor St, Chicago, IL 60613.