Asthma, rhinitis, other respiratory diseasesExhaled nitric oxide levels correlate with measures of disease control in asthma☆,☆☆
Section snippets
Methods
We conducted a cross-sectional survey of patients with physician-diagnosed asthma whose cases were followed by allergy specialists in two community-based practices in Portland, Oregon. Our institutional review board approved the research protocol, and written informed consent was obtained from all subjects. Inclusion criteria included both a history of physician-diagnosed asthma11 and current use of antiasthma medications. Patients were excluded if they were currently smoking or if they had
Results
The mean age of participants was 41.8 ± 18 years (range, 7-80 years), and the majority of subjects were female (Table I).
Variable Empty Cell Age, y (mean ± SD) 41.8 ± 18 Sex, F (%) 72 Race, white (%) 97 Hospital-based asthma care during past year (%) 15 Burst of prednisone during past year (%) 38 Current steroid inhaler use (%) 55 Less severe asthma (validated asthma severity score*; %) 89 Ever smoker (%) 19 Current smoker (%) 0 Atopy (self-reported hay
Discussion
The results of this study support the concept that exhaled NO levels correlate with measures of asthma control, as defined by recent symptoms or dyspnea, use of rescue medications, and reversibility of airflow obstruction. Exhaled NO levels did not correlate with several measures of asthma severity, including a history of mechanical ventilation, health care use in the past year, fixed airflow obstruction, or a validated asthma severity score.9
Although our findings may suggest a clinical role
Acknowledgements
We thank the Portland, Oregon, VAMC, for the use of space and equipment provided for this study.
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2021, World Allergy Organization JournalThe beneficial role of FeNO in association with GINA guidelines for titration of inhaled corticosteroids in adult asthma: A randomized study
2020, Advances in Medical SciencesCitation Excerpt :However, FeNO has not only been used as an inflammatory biomarker for diagnosis and treatment of asthmatic patients, but it has also been considered as a useful tool for asthma control. Previous study by Sippel et al. [9] showed that the level of FeNO was correlated with the frequency of asthma symptoms, as well as the level of asthma control. The significant increase of FeNO level in asthmatic patients may predict the risk of asthma exacerbation or loss of asthma control [8].
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2017, Personalizing Asthma Management for the ClinicianGastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma
2016, Allergology InternationalCitation Excerpt :However, the effect of gastroesophageal dysmotility on the pathophysiology of “cough hypersensitivity syndrome” in patients with CVA remains to be further clarified. Previous studies showed that levels of FEV1, AHR, and FeNO correlated with wheezing39–42 and dyspnea39,43,44 in patients with asthma. Meanwhile, there were no association of FEV1,7,39 AHR,7,40,41 or FeNO7 with cough frequency, as well as those with cough-specific QoL8 in patients with asthma.
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Supported by The American Lung Association of Oregon.
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Reprint requests: Molly L. Osborne, MD, PhD, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd #L102, Portland, OR 97201-3098.