Background To investigate 576 patients undergoing coronary artery bypass grafting (CABG) and to evaluate independent high risk factors of postoperative hypoxemia following CABG. Methods and Results The pre-, intra-, and post-operative materials in patients who had CABG performed on them from March 2004 to March 2008 in our hospital were analyzed retrospectively. The relative factors of postoperative hypoxemia were tested through descriptive analysis and logistic regression, and the independent risk factors were obtained. Among the 576 patients investigated, 156 cases suffered from postoperative hypoxemia, and the incidence rate of postoperative hypoxemia was 27.08%. Through descriptive analysis and logistic regression, the independent risk factors of postoperative hypoxemia were as follows: preoperative chronic pulmonary diseases (odds ratio (OR)=8.531, 95% confidence interval (CI) 3.136-23.210), preoperative acute myocardial infarction (OR=3.351, 95% CI 1.539-7.296), and preoperative diabetes (OR=3.108, 95% CI 1.439-6.713). Preoperative acute myocardial infarction (OR=2.091, 95% CI 1.520-4.416) is the independent risk factor during assisted ventilation after surgery, and preoperative chronic pulmonary diseases (OR=7.19, 95% CI 2.807-18.413), pre-operative diabetes (OR=3.605, 95% CI 1.631-7.967), and preoperative acute myocardial infarction (OR=3.604, 95% CI 1.518-8.543) are the 3 independent risk factors after decannulation following CABG. Conclusions Preoperative chronic pulmonary diseases, preoperative acute myocardial infarction, and preoperative diabetes are 3 independent risk factors of postoperative hypoxemia following CABG. (Circ J 2008; 72: 1975 - 1980)