Chest
Original Research: Sleep MedicineRelationship Between β-Blocker Treatment and the Severity of Central Sleep Apnea in Chronic Heart Failure
Section snippets
Patients
Between January 2004 and May 2005, 45 consecutive patients (31 men and 14 women; mean age ± SD, 64 ± 13 years) with chronic heart failure who were admitted to our hospital and who met the following criteria were enrolled into this study. Inclusion criteria were chronic heart failure with New York Heart Association (NYHA) functional class II or III and left ventricular ejection fraction (LVEF) < 50%. Exclusion criteria were previous cerebrovascular disease, recent (< 6 months) acute coronary
Results
Clinical characteristics of patients studied are shown inTable 1. The β-blocker administered was carvedilol. Of 18 patients not receiving β-blockers, 14 patients received β-blockers at a later time, and 4 patients were not treated with β-blockers because of hypotension and bradycardia. Patients receiving β-blocker treatment (n = 27) had lower AHI and CAI than those not receiving β-blocker treatment (n = 18) [14 ± 11 vs 33 ± 17, p < 0.0001; and 1.9 ± 3.2 vs 11 ± 12, p = 0.0004, respectively].
Discussion
The major findings of the present study are as follows: (1) patients with chronic heart failure receiving β-blocker therapy had lower AHI and CAI than patients not receiving β-blocker therapy; (2) the dose of carvedilol was negatively correlated with AHI and CAI; (3) the multiple regression analysis selected no use of β-blockers as an independent factor of CAI; and (4) 6 months of treatment with carvedilol decreased CAI in five patients with CAI > 5 who underwent serial sleep studies. These
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